ChemicalBook > CAS DataBase List > DC661

DC661

Product Name
DC661
CAS No.
1872387-43-3
Chemical Name
DC661
Synonyms
DC661;DC-661;DC 661;DC661, 10 mM in DMSO;inhibit,Inhibitor,Autophagy,Apoptosis,DC-661,DC 661,DC661;N'-(7-Chloro-4-quinolinyl)-N-{6-[(7-chloro-4-quinolinyl)amino]hexyl}-N-methyl-1,6-hexanediamine;N1-(7-Chloroquinolin-4-yl)-N6-(6-((7-chloroquinolin-4-yl)amino)hexyl)-N6-methylhexane-1,6-diamine;1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl-
CBNumber
CB24800859
Molecular Formula
C31H39Cl2N5
Formula Weight
552.58
MOL File
1872387-43-3.mol
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DC661 Property

Boiling point:
726.8±60.0 °C(Predicted)
Density 
1.210±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 25 mg/ml; Ethanol: 15 mg/ml
form 
A solid
pka
9.77±0.50(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb573232
Product name
DC661
Purity
>98%
Packaging
100mg
Price
$1208.7
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573232
Product name
DC661
Purity
>98%
Packaging
250mg
Price
$1802
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573232
Product name
DC661
Purity
>98%
Packaging
1g
Price
$3580.2
Updated
2021/12/16
DC Chemicals
Product number
DC12554
Product name
DC661
Purity
>98%
Packaging
1g
Price
$2400
Updated
2021/12/16
DC Chemicals
Product number
DC12554
Product name
DC661
Purity
>98%
Packaging
100mg
Price
$800
Updated
2021/12/16
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DC661 Chemical Properties,Usage,Production

Uses

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity[1].

Biological Activity

DC661 is able to deacidify lysosomes and significantly inhibit autophagy, which is more effective than hydroxychloroquine (HCQ). It induces apoptosis.

in vitro

Treatment of melanoma cells with DC661 induced the accumulation of the autophagic vacuole marker LC3B-II, which was more pronounced and lower than that of Lys05 or HCQ. At concentrations of it greater than 10 μM, all cells died. Compared with HCQ and Lys05, DC661 inhibited autophagic flux more significantly in melanoma cells expressing the mCherry-eGFP-LC3B reporter gene; in melanoma cells expressing the GFP-LC3B reporter gene, the expression level was higher of free GFP levels. It can cause a more pronounced lysosomal deacidification effect. In a variety of cancer cell lines, including colon and pancreatic cancer cells, the IC50 of DC661 was 100-fold lower than that of HCQ as measured by MTT assay after 72 hours of drug incubation. In BRAF-mutated melanoma cell lines, it inhibited the clonal growth of long-term melanoma cells more effectively and induced more apoptosis than Lys05, HCQ or BRAF/MEK dual inhibition conditions.

in vivo

In the HT29 xenograft model, intraperitoneal injection of 3 mg/kg DC661 caused a significant decrease in tumor volume, and the daily tumor growth rate was completely inhibited several times. but did not affect the body weight of mice.

target

References

[1] Rebecca VW, et al. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. ancer Discov. 2019 Feb;9(2):220-229. DOI:10.1158/2159-8290.CD-18-0706

DC661 Preparation Products And Raw materials

Raw materials

Preparation Products

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DC661 Suppliers

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1872387-43-3, DC661Related Search:


  • DC661
  • DC-661;DC 661
  • 1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl-
  • N'-(7-Chloro-4-quinolinyl)-N-{6-[(7-chloro-4-quinolinyl)amino]hexyl}-N-methyl-1,6-hexanediamine
  • inhibit,Inhibitor,Autophagy,Apoptosis,DC-661,DC 661,DC661
  • N1-(7-Chloroquinolin-4-yl)-N6-(6-((7-chloroquinolin-4-yl)amino)hexyl)-N6-methylhexane-1,6-diamine
  • DC661, 10 mM in DMSO
  • 1872387-43-3
  • C31H39Cl2N5
  • API
    • TargetValue
    Autophagy
    ()