Methuosis inducer

Product Name: Methuosis inducer
CAS No.: 2240205-30-3
Chemical Name: Methuosis inducer
Synonyms: Methuosis inducer;Methuosis inducer 1;Methuosis inducer 1, 10 mM in DMSO;Inhibitor,Methuosis inducer 1,Methuosis inducer-1,inhibit,Methuosis inducer1;Benzamide, N-[4-methyl-3-[[6-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]phenyl]-3-(trifluoromethyl)-
CBNumber: CB24819512
Molecular Formula: C27H20F3N5O
Formula Weight: 487.48
MOL File: 2240205-30-3.mol

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Methuosis inducer Property

Density: 1.399±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (51.28 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
form: Solid
pka: 12.81±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Methuosis inducer Chemical Properties,Usage,Production

Uses

HZX-02-059 is a potent methuosis inducer and dual-target PIKfyve/tubulin inhibitor with anticancer activity. Methuosis mainly disrupts the balance of endocytosis and exocytosis, forming a large number of vesicles and inducing cell death. HZX-02-059 also induces cell vacuolization, promotes apoptosis, downregulates the p53 pathway, inhibits PI3K/AKT phosphorylation, and inhibits c-Myc and NF-κB transcription[1][2].

Biological Activity

Methuosis inducer 1 is a potent methuosis inducer[1]. Anticancer activity[1]. Methuosis inducer 1 (Compound 13) shows a broad spectrum of cytotoxicity against a panel of human cancer cell lines with IC50 values of 0.326±0.026 μM, 1.370±0.061 μM, 1.662±0.128 μM, 1.892±0.092 μM, 1.571±0.066 μM, 2.268±0.100 μM, 2.611±0.739 μM, 1.008±0.042 μM, 1.566±0.015 μM, and 1.197±0.344 μM for A375, SK-MEL-28, SK-MEL-30, A549, MDA-MB-231, MDA-MB-435S, MCF-7, HCT116, BGC823, HepG2 cells, respectively[1].

References

[1]. Huang W, et al. Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities. J Med Chem. 2018 Jun 28;61(12):5424-5434.

Methuosis inducer Preparation Products And Raw materials

Raw materials

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Methuosis inducer Suppliers

China 15 United States 1 Global 16

ShangHai Biochempartner Co.,Ltd

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2240205-30-3, Methuosis inducerRelated Search:

Methuosis inducer

Methuosis inducer 1

Inhibitor,Methuosis inducer 1,Methuosis inducer-1,inhibit,Methuosis inducer1

Benzamide, N-[4-methyl-3-[[6-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]phenyl]-3-(trifluoromethyl)-

Methuosis inducer 1, 10 mM in DMSO

2240205-30-3