Oxaceprol
- Product Name
- Oxaceprol
- CAS No.
- 33996-33-7
- Chemical Name
- Oxaceprol
- Synonyms
- NAHP;CO-61;AHP-200;Jonctum;Ac-L-Hyp;AC-HYP-OH;OXACEPROL;trans<;N-AC-L-HYP;Ac-L-Hyp-OH
- CBNumber
- CB2482503
- Molecular Formula
- C7H11NO4
- Formula Weight
- 173.17
- MOL File
- 33996-33-7.mol
Oxaceprol Property
- Melting point:
- 132-133 °C (dec.)(lit.)
- alpha
- -119 º (c=4 in H2O)
- Boiling point:
- 303.8°C (rough estimate)
- Density
- 1.3346 (rough estimate)
- vapor pressure
- 0Pa at 20℃
- refractive index
- 1.4490 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO : ≥ 32 mg/mL (184.79 mM)
- pka
- 3.48±0.40(Predicted)
- form
- Crystalline Powder
- color
- White
- optical activity
- [α]20/D 119°, c = 4 in H2O
- Merck
- 14,6903
- BRN
- 84043
- InChIKey
- BAPRUDZDYCKSOQ-RITPCOANSA-N
- LogP
- -1.51 at 20℃
- CAS DataBase Reference
- 33996-33-7(CAS DataBase Reference)
- EPA Substance Registry System
- L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 441562
- Product name
- trans-1-Acetyl-4-hydroxy-L-proline
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $175
- Updated
- 2025/07/31
- Product number
- 260538
- Product name
- Acetyl-L-4-hydroxyproline
- Packaging
- 50g
- Price
- $326
- Updated
- 2021/12/16
- Product number
- FA47431
- Product name
- Acetyl-L-4-hydroxyproline
- Packaging
- 500g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 02614
- Product name
- Acetyl-L-trans-4-hydroxyproline,95%(TLC)
- Purity
- 95%(TLC)
- Packaging
- 25G
- Price
- $509.6
- Updated
- 2021/12/16
- Product number
- AAA0001569
- Product name
- N-ACETYL-HYPHYDROXYPROLINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $816
- Updated
- 2021/12/16
Oxaceprol Chemical Properties,Usage,Production
Chemical Properties
White powder
Originator
Jonctum,Merrell,France,1970
Uses
trans-1-Acetyl-4-hydroxy-L-proline can be used:
- In the stereospecific synthesis of 4-fluoroglutamic acid.
- To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
- As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).
Manufacturing Process
16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C.
Therapeutic Function
Antirheumatic
Flammability and Explosibility
Not classified
reaction suitability
reaction type: solution phase peptide synthesis
Oxaceprol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Oxaceprol manufacturers
- Product
- N-Acetyl-L-hydroxyproline 33996-33-7
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-09-26
- Product
- Oxaceprol 33996-33-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- Oxaceprol 33996-33-7
- Price
- US $79.00-38.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-11-21