5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE
- Product Name
- 5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE
- CAS No.
- 76153-06-5
- Chemical Name
- 5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE
- Synonyms
- 3-methyl-5-bromo-o-phenylenediamine;5-Bromo-3-methyl-1,2-diaminobenzene;5-BROMO-3-METHYL-1,2-BENZENEDIAMINE;5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE;1,2-Benzenediamine, 5-bromo-3-methyl-
- CBNumber
- CB2482679
- Molecular Formula
- C7H9BrN2
- Formula Weight
- 201.06
- MOL File
- 76153-06-5.mol
5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE Property
- Melting point:
- 63 °C
- Boiling point:
- 298.8±35.0 °C(Predicted)
- Density
- 1.589±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.31±0.10(Predicted)
- Appearance
- Brown to dark brown Solid
- InChI
- InChI=1S/C7H9BrN2/c1-4-2-5(8)3-6(9)7(4)10/h2-3H,9-10H2,1H3
- InChIKey
- UOFSLKHZOPVGHG-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(Br)=CC(C)=C1N
- CAS DataBase Reference
- 76153-06-5
Safety
- HazardClass
- IRRITANT
- HS Code
- 2921599090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B677968
- Product name
- 5-Bromo-3-methylbenzene-1,2-diamine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 044715
- Product name
- 5-Bromo-3-methyl-1,2-benzenediamine
- Purity
- >95%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- Z5108
- Product name
- 5-Bromo-3-methylbenzene-1,2-diamine
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 3730-9-19
- Product name
- 5-Bromo-3-methylbenzene-1,2-diamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- 044715
- Product name
- 5-Bromo-3-methyl-1,2-benzenediamine
- Purity
- >95%
- Packaging
- 5g
- Price
- $215
- Updated
- 2021/12/16
5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE Chemical Properties,Usage,Production
Uses
5-Bromo-3-methylbenzene-1,2-diamine is used as an intermediate in organic synthesis.
Synthesis
77811-44-0
76153-06-5
Step 1: Stannous chloride (SnCl2, 5.0 g, 26.1 mmol) was added to an ethanol (EtOH, 20 mL) suspension of 4-bromo-2-methyl-6-nitroaniline (2.0 g, 8.7 mmol). The reaction mixture was heated to reflux for 14 h, followed by cooling to room temperature and vacuum concentration. The residue was diluted with ethyl acetate (EtOAc, 100 mL) and partitioned between saturated aqueous sodium bicarbonate (NaHCO3) solution (200 mL) and water. The resulting slurry was filtered through a Celite pad and the wet filter cake was washed with ethyl acetate (3 x 50 mL). The filtrate was washed sequentially with saturated aqueous sodium bicarbonate, water, and brine, dried over anhydrous magnesium sulfate (MgSO4), filtered, and concentrated in vacuum to give 1.27 g (72% yield) of 5-bromo-3-methylbenzene-1,2-diamine (72) as a yellow oil: mass spectrum (ESI) m/z = 201.1 [M + 1]+.
References
[1] Patent: WO2013/26914, 2013, A1. Location in patent: Page/Page column 130
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 11, p. 3072 - 3076
[3] Patent: US2005/54655, 2005, A1. Location in patent: Page/Page column 15-16
[4] Patent: US2004/44203, 2004, A1. Location in patent: Page 28
[5] Chemische Berichte, 1884, vol. 17, p. 776
5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE manufacturers
- Product
- 5-BROMO-3-METHYL-BENZENE-1,2-DIAMINE 76153-06-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09