PubChem ID: 397887

Product Name: PubChem ID: 397887
CAS No.: 308246-57-3
Chemical Name: PubChem ID: 397887
Synonyms: Mj-III-65;LMP744 HCl;PubChem ID: 397887;LMP744 hydrochloride;MJ-III65 hydrochloride;NSC706744 hydrochloride);LMP744/MJ-III65/NSC706744 hydrochloride;LMP744; LMP-744; LMP 744; MJ-III-65; NSC-706744;LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride;6-(3-((2-Hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione hydrochloride
CBNumber: CB24840275
Molecular Formula: C24H25ClN2O7
Formula Weight: 488.92
MOL File: 308246-57-3.mol

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PubChem ID: 397887 Property

Melting point:: 284-288 °C
storage temp.: Store at -20°C
solubility: DMSO : 5.56 mg/mL (11.37 mM)
form: Solid
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0086159
Product name: LMP744hydrochloride
Purity: 99.21%
Packaging: 1mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0086159
Product name: LMP744hydrochloride
Purity: 99.21%
Packaging: 5mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0086159
Product name: LMP744hydrochloride
Purity: 99.21%
Packaging: 50mg
Price: $1100
Updated: 2021/12/16

DC Chemicals

Product number: DC20275
Product name: LMP744
Purity: >98%
Packaging: 250mg
Price: $1700
Updated: 2021/12/16

DC Chemicals

Product number: DC20275
Product name: LMP744
Purity: >98%
Packaging: 1g
Price: $3200
Updated: 2021/12/16

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PubChem ID: 397887 Chemical Properties,Usage,Production

Uses

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

in vivo

LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity^[1].

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts^[1].
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

IC 50

Top1

References

[1] Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. DOI:10.1124/mol.104.003889
[2] Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 DOI:10.1124/mol.106.024372

PubChem ID: 397887 Preparation Products And Raw materials

Raw materials

Preparation Products

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PubChem ID: 397887 Suppliers

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308246-57-3, PubChem ID: 397887Related Search:

PubChem ID: 397887

LMP744 hydrochloride

LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride

NSC706744 hydrochloride)

LMP744; LMP-744; LMP 744; MJ-III-65; NSC-706744

Mj-III-65

MJ-III65 hydrochloride

LMP744 HCl

Inhibitor,NSC 706744,LMP744,inhibit,LMP744 hydrochloride,LMP-744,Topoisomerase,LMP-744 hydrochloride,NSC706744,NSC-706744,MJ-III65,LMP 744

LMP744/MJ-III65/NSC706744 hydrochloride

6-(3-((2-Hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione hydrochloride

308246-57-3

C24H25ClN2O7