[2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid

Product Name: [2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid
CAS No.: 1648843-04-2
Chemical Name: [2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid
Synonyms: SX-682;2-[[[5-[(4-Fluorophenyl)carbamoyl]-2-pyrimidinyl]thio]methyl]-4-(trifluoromethoxy)phenylboronic Acid;(2-(((5-((4-fluorophenyl)carbamoyl)pyrimidin-2-yl)thio)methyl)-4-(trifluoromethoxy)phenyl)boronic acid;[2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid;Boronic acid, B-[2-[[[5-[[(4-fluorophenyl)amino]carbonyl]-2-pyrimidinyl]thio]methyl]-4-(trifluoromethoxy)phenyl]-;cells,SX-682,allosteric,SX 682,recruitment,suppressor,Inhibitor,tumor,CXCR,CXC chemokine receptors,SX682,immunity,MDSCs,inhibit,myeloid-derived,antitumor
CBNumber: CB24840361
Molecular Formula: C19H14BF4N3O4S
Formula Weight: 467.2
MOL File: 1648843-04-2.mol

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[2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid Property

Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 8.18±0.53(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0067128
Product name: SX-682
Purity: 98.52%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0067128
Product name: SX-682
Purity: 98.52%
Packaging: 10mg
Price: $270
Updated: 2021/12/16

ChemScene

Product number: CS-0067128
Product name: SX-682
Purity: 98.52%
Packaging: 25mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-0067128
Product name: SX-682
Purity: 98.52%
Packaging: 50mg
Price: $870
Updated: 2021/12/16

ChemScene

Product number: CS-0067128
Product name: SX-682
Purity: 98.52%
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

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[2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid Chemical Properties,Usage,Production

Description

SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM).1?It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5

References

Zebala et al. (2015), WO2015/016938 Lu et al. (2017), Effective combinatorial immunotherapy for castration-resistant prostate cancer; Nature 542 728 Kargl et al. (2019), Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC; JCI Insight 4 e130850 Sun et al. (2019), Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy; JCI Insight 4 e126853 Greene et al. (2020), Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models; Clin. Cancer Res. 26 1420

[2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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[2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid Suppliers

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1648843-04-2, [2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acidRelated Search:

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[2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid

SX-682

Boronic acid, B-[2-[[[5-[[(4-fluorophenyl)amino]carbonyl]-2-pyrimidinyl]thio]methyl]-4-(trifluoromethoxy)phenyl]-

(2-(((5-((4-fluorophenyl)carbamoyl)pyrimidin-2-yl)thio)methyl)-4-(trifluoromethoxy)phenyl)boronic acid

cells,SX-682,allosteric,SX 682,recruitment,suppressor,Inhibitor,tumor,CXCR,CXC chemokine receptors,SX682,immunity,MDSCs,inhibit,myeloid-derived,antitumor

2-[[[5-[(4-Fluorophenyl)carbamoyl]-2-pyrimidinyl]thio]methyl]-4-(trifluoromethoxy)phenylboronic Acid

1648843-04-2

C19H14BF4N3O4S