N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine

Product Name: N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine
CAS No.: 2305416-07-1
Chemical Name: N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine
Synonyms: N2-[(N,N-Dimethylamino]methylene-N1-methyl-2’-O-methylguanosine;N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine;(E)-N'-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1-methyl-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide
CBNumber: CB24842158
Molecular Formula: C15H22N6O5
Formula Weight: 366.38
MOL File: 2305416-07-1.mol

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N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine Property

Boiling point:: 660.4±65.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
pka: 13.20±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine Chemical Properties,Usage,Production

Uses

N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100

N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine Suppliers

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2305416-07-1, N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosineRelated Search:

N2-METHYLGUANOSINE 2'-DEOXY-N2-DIMETHYLAMINOMETHYLENE-GUANOSINE GUANOSINE HYDRATE Guanosine, N-[(diMethylaMino)Methylene]-2'-O-Methyl- N1-METHYL-2'-DEOXYGUANOSINE

N2-[(N,N-Dimethylamino] methylene-N1-methyl-2'-O-methylguanosine

N2-[(N,N-Dimethylamino]methylene-N1-methyl-2’-O-methylguanosine

(E)-N'-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1-methyl-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

2305416-07-1