4-AMINO-3-HYDROXY-BENZONITRILE
用途- Product Name
- 4-AMINO-3-HYDROXY-BENZONITRILE
- CAS No.
- 55586-26-0
- Chemical Name
- 4-AMINO-3-HYDROXY-BENZONITRILE
- Synonyms
- 4-AMINO-3-HYDROXY-BENZONITRILE;Benzonitrile, 4-amino-3-hydroxy-
- CBNumber
- CB2484365
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 55586-26-0.mol
4-AMINO-3-HYDROXY-BENZONITRILE Property
- Melting point:
- 149-150 °C
- Boiling point:
- 314.1±37.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- powder
- pka
- 8.37±0.10(Predicted)
- color
- Brown
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- OR17680
- Product name
- 4-Amino-3-hydroxybenzonitrile
- Packaging
- 250mg
- Price
- $183
- Updated
- 2021/12/16
- Product number
- 4656-1-0U
- Product name
- 4-Amino-3-hydroxybenzonitrile
- Packaging
- 250mg
- Price
- $202
- Updated
- 2021/12/16
- Product number
- Z4880
- Product name
- 4-Amino-3-hydroxybenzonitrile
- Packaging
- 100mg
- Price
- $251
- Updated
- 2021/12/16
- Product number
- FA140779
- Product name
- 4-Amino-3-hydroxybenzonitrile
- Packaging
- 250mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- Z4880
- Product name
- 4-Amino-3-hydroxybenzonitrile
- Packaging
- 250mg
- Price
- $451
- Updated
- 2021/12/16
4-AMINO-3-HYDROXY-BENZONITRILE Chemical Properties,Usage,Production
用途
4-氨基-3-羟基-苯甲腈用作研究用化合物。
Synthesis
18495-15-3
55586-26-0
The general procedure for the synthesis of 4-amino-3-hydroxybenzonitrile from 3-hydroxy-4-nitrobenzonitrile was as follows: 3-hydroxy-4-nitrobenzonitrile (1.6 g, 9.6 mmol) was dissolved in a solvent mixture of ethanol (40 mL) and N,N-dimethylformamide (20 mL). Palladium hydroxide (30 mg) was added to this solution to form a reaction mixture. The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the solvent was subsequently removed by distillation under reduced pressure. The residue was dried to afford crystals of 4-amino-3-hydroxybenzonitrile (771 mg, 60% yield). The product was characterized by 1H-NMR (DMSO-d6) with the following chemical shifts: δ 5.57 (2H, broad peak), 6.62 (1H, double peak, J = 8.4 Hz), 6.86 (1H, double peak, J = 2.2 Hz), and 6.99 (1H, double-double peak, J = 1.9 Hz, 8.1 Hz).
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 6, p. 1319 - 1321
[2] Journal of the American Chemical Society, 2012, vol. 134, # 44, p. 18193 - 18196
[3] Patent: US2017/298081, 2017, A1. Location in patent: Paragraph 0307; 0310; 0311
[4] Fortsch. Ch. Phys., 1924, vol. 18, p. Heft 2, S. 37
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 12, p. 1545 - 1548
4-AMINO-3-HYDROXY-BENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-3-HYDROXY-BENZONITRILE manufacturers
- Product
- 4-Amino-3-hydroxybenzonitrile 55586-26-0
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20