2BAct(eIF2B activator 2BAct)

Product Name: 2BAct(eIF2B activator 2BAct)
CAS No.: 2143542-28-1
Chemical Name: 2BAct(eIF2B activator 2BAct)
Synonyms: 2BAct;2BAct, 10 mM in DMSO;2BAct(eIF2B activator 2BAct);N-(3-(2-(4-Chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide;2-Pyrazinecarboxamide, N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-;permeable,primary,inhibit,Eukaryotic Initiation Factor (eIF),2BAct,stress,defects,response,fibroblast,neurological,Inhibitor,CNS
CBNumber: CB24844420
Molecular Formula: C19H16ClF3N4O3
Formula Weight: 440.8
MOL File: 2143542-28-1.mol

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2BAct(eIF2B activator 2BAct) Property

Boiling point:: 671.6±55.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
solubility: DMSO: soluble
form: A solid
pka: 12.16±0.40(Predicted)
color: Light yellow to light brown

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Hazard and Precautionary Statements (GHS)

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2BAct(eIF2B activator 2BAct) Chemical Properties,Usage,Production

Uses

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1].

in vivo

2BAct (300 μg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice^[1].
2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice^[1].
2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response^[1].

IC 50

eIF2

References

[1] Wong YL, et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019;8:e42940. Published 2019 Jan 9. DOI:10.7554/eLife.42940

2BAct(eIF2B activator 2BAct) Preparation Products And Raw materials

Raw materials

Preparation Products

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2143542-28-1, 2BAct(eIF2B activator 2BAct)Related Search:

2BAct(eIF2B activator 2BAct)

2BAct

2-Pyrazinecarboxamide, N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-

N-(3-(2-(4-Chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide

permeable,primary,inhibit,Eukaryotic Initiation Factor (eIF),2BAct,stress,defects,response,fibroblast,neurological,Inhibitor,CNS

2BAct, 10 mM in DMSO

2143542-28-1