AS2717638

Product Name: AS2717638
CAS No.: 2148339-28-8
Chemical Name: AS2717638
Synonyms: AS2717638;AS2717638,AS-2717638;AS2717638, 10 mM in DMSO;1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-
CBNumber: CB24844480
Molecular Formula: C25H25N3O5
Formula Weight: 447.48
MOL File: 2148339-28-8.mol

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AS2717638 Property

Boiling point:: 712.5±60.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 2 mg/ml; DMSO: 2 mg/ml
form: A solid
pka: -1.17±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0084785
Product name: AS2717638
Purity: 98.07%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0084785
Product name: AS2717638
Purity: 98.07%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

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AS2717638 Chemical Properties,Usage,Production

Biological Activity

Orally active, potent and selective lysophosphatidic acid (LPA) receptor LPAR5 (LPA5) antagonist with analgesic efficacy in vivo.

AS2717638 is an orally active, potent and selective lysophosphatidic acid (LPA) receptor LPAR5 (LPA5) antagonist (h/m/r LPA5 Ki = 9.1/7.3/16 nM) th at blocks LPA-induced activation of human LPA5-expressing cells (cAMP accumulation IC50 = 38 nM), but not LPA1, LPA2 or LPA3 transfectants (Ca2+ mobilization IC50 >10 μM) and displays much reduced or little affinity toward 20 other receptors and channels. AS2717638 exhibits analgesic efficacy in mice (10 & 30 mg/kg p.o. against allodynia caused by 10 ng PGE2, 300 ng PGF2α, or 3 ng AMPA per mouse via i.t.) and rats (10 mg/kg p.o. against mechanical allodynia, thermal hyperalgesia and adjuvant-induced inflammatory pain) in vivo.

storage

Store at -20°C

AS2717638 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS2717638 Suppliers

China 15 United States 4 Global 19

Shanghai EFE Biological Technology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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DC Chemicals

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TargetMol Chemicals Inc.

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Changsha Fuzhen Biotechnology Co.，LTD

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2148339-28-8, AS2717638Related Search:

AS2717638

1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-

AS2717638,AS-2717638

AS2717638, 10 mM in DMSO

2148339-28-8