ChemicalBook > CAS DataBase List > CB-6644

CB-6644

Product Name
CB-6644
CAS No.
2316817-88-4
Chemical Name
CB-6644
Synonyms
Chb-M';CB-6644;CB-6644 (CB6644;CB6644,CB-6644,Inhibitor,CB 6644,inhibit;5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide;Benzamide, 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-
CBNumber
CB24844617
Molecular Formula
C29H34ClFN4O5
Formula Weight
573.06
MOL File
2316817-88-4.mol
More
Less

CB-6644 Property

Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);174.5(Max Conc. mM)
form 
A solid
pka
13.13±0.20(Predicted)
color 
White to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

CB-6644 Chemical Properties,Usage,Production

Biological Activity

CB-6644 is a selective RUVBL1/2 complex inhibitor. It inhibits the ATPase activity of RUVBL1/2 with IC50 of 15 nM; it also has anticancer activity.

in vitro

CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells.
CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (including HCT116, NCI -1975, and HT29 cells) with an EC 50 range of 41 to 785 nM.

Cell Viability Assay

Cell Line: 123 cell lines such as HCT116, NCI-1975, and HT29 cells
Concentration: 0.001, 0.01, 0.1, 1, and 10 μM
Incubation Time: 72 hours
Result: Potently killed cells with an EC 50 range of 41 to 785 nM.

in vivo

CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

Animal Model: SCID-beige mice bearing human tumor xenografts derived from either Burkitt's lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines
Dosage: < /td> 150 mg/kg
Administration: Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226
Result: There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively.

CB-6644 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CB-6644 Suppliers

China 25 United States 6 Global 31
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
993
Advantage
64
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Tel
15317229551
Fax
QQ:3607245178
Email
15151849396@163.com
Country
China
ProdList
996
Advantage
58
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4331
Advantage
58
Tel
4000-360-990 15268198094
Email
sales@torreybio.com
Country
China
ProdList
2916
Advantage
58
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Tel
024-024-88590548 18341751992
Email
757984502@qq.com
Country
China
ProdList
930
Advantage
58
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5018
Advantage
58
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Tel
13915962545
Email
2881759498@qq.com
Country
China
ProdList
4891
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
73043
Advantage
58
Tel
+86-18341751992 +86-15382112998
Email
757984502@qq.com
Country
China
ProdList
892
Advantage
58
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
24727
Advantage
58
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6682
Advantage
58
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

2316817-88-4, CB-6644Related Search:


  • CB-6644
  • CB-6644 (CB6644
  • Chb-M'
  • CB6644,CB-6644,Inhibitor,CB 6644,inhibit
  • Benzamide, 5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-
  • 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide
  • 2316817-88-4