ChemicalBook > CAS DataBase List > COH-SR4 (Mitochondria uncoupler SR4)

COH-SR4 (Mitochondria uncoupler SR4)

Product Name: COH-SR4 (Mitochondria uncoupler SR4)
CAS No.: 73439-19-7
Chemical Name: COH-SR4 (Mitochondria uncoupler SR4)
Synonyms: COH-SR4;COH-SR4, 10 mM in DMSO;AMPK Activator, COH-SR4;Urea, N,N'-bis(3,5-dichlorophenyl)-;COH-SR4 (Mitochondria uncoupler SR4);anticancer,anti-proliferative,kinase,leukemia,protein,breast,cancers,lung,COH SR4,COHSR4,anti-adipogenic,COH-SR-4,Inhibitor,AMPK,melanoma,inhibit,COH-SR4,AMP-activated protein kinase,AMP-activated
CBNumber: CB24844657
Molecular Formula: C13H8Cl4N2O
Formula Weight: 350.03
MOL File: 73439-19-7.mol

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COH-SR4 (Mitochondria uncoupler SR4) Property

Melting point:: 298-300 °C
Boiling point:: 363.2±42.0 °C(Predicted)
Density: 1.608±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (357.11 mM; Need ultrasonic)
form: Solid
pka: 12.42±0.70(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B426330
Product name: N,N''-Bis(3,5-dichlorophenyl)-urea
Packaging: 250mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0087812
Product name: COH-SR4
Purity: 99.73%
Packaging: 25mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0087812
Product name: COH-SR4
Purity: 99.73%
Packaging: 50mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0087812
Product name: COH-SR4
Purity: 99.73%
Packaging: 100mg
Price: $120
Updated: 2021/12/16

Ambeed

Product number: A1103292
Product name: 1,3-Bis(3,5-dichlorophenyl)urea
Purity: 98+%
Packaging: 25mg
Price: $127
Updated: 2021/12/16

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COH-SR4 (Mitochondria uncoupler SR4) Chemical Properties,Usage,Production

Uses

N,N'-Bis(3,5-dichlorophenyl)-urea is a by-product during the synthesis of Vinclozolin (V314050), which is an agricultural fungicide.

Biological Activity

Cell permeable: yes

in vivo

COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake^[2].
COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice^[2].
COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice^[2].
COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice^[2].

Animal Model:	Nine-week old male C57BL/6J mice^[2]
Dosage:	5 mg/kg
Administration:	Oral gavage, three times a week, for 6 weeks
Result:	Decreased body weight and fat mass in HFD obese mice.

COH-SR4 (Mitochondria uncoupler SR4) Preparation Products And Raw materials

Raw materials

Preparation Products

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73439-19-7, COH-SR4 (Mitochondria uncoupler SR4)Related Search:

COH-SR4 (Mitochondria uncoupler SR4)

Urea, N,N'-bis(3,5-dichlorophenyl)-

COH-SR4

anticancer,anti-proliferative,kinase,leukemia,protein,breast,cancers,lung,COH SR4,COHSR4,anti-adipogenic,COH-SR-4,Inhibitor,AMPK,melanoma,inhibit,COH-SR4,AMP-activated protein kinase,AMP-activated

COH-SR4, 10 mM in DMSO

AMPK Activator, COH-SR4

73439-19-7