ChemicalBook > CAS DataBase List > DDR-TRK-1
(DDR1 inhibitor 6j)
DDR-TRK-1 (DDR1 inhibitor 6j)
- Product Name
- DDR-TRK-1 (DDR1 inhibitor 6j)
- CAS No.
- 1934246-19-1
- Chemical Name
- DDR-TRK-1 (DDR1 inhibitor 6j)
- Synonyms
- DDR-TRK-1;DDRTRK1,DDR TRK 1;DDR-TRK-1, 10 mM in DMSO;DDR-TRK-1 (DDR1 inhibitor 6j);7-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(5-pyrimidinyl)-, (4R)-
- CBNumber
- CB24844697
- Molecular Formula
- C26H23F3N6O
- Formula Weight
- 492.5
- MOL File
- 1934246-19-1.mol
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DDR-TRK-1 (DDR1 inhibitor 6j) Property
- Boiling point:
- 609.3±55.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.84±0.70(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -25 to -20°, c =0.5 in methanol
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DDR-TRK-1 (DDR1 inhibitor 6j) Chemical Properties,Usage,Production
Biological Activity
DDR-TRK-1 was shown to inhibit the kinase activity of Discoidin Domain Receptor 1 (DDR1) with an IC50 value of 9.4 nM. DDR receptors are linked to the progression of various human diseases, including fibrotic disorders such as pulmonary fibrosis, as well as atherosclerosis and cancer. DDR-TRK-1 showed a therapeutic effect in a mouse model of pulmonary fibrosis and inhibited Panc-1 pancreatic cancer cell colony formation and migration. DDR-TRK-1 also inhibits the TRK family kinases TRKA, TRKB, and TRKC, which are selectively expressed in neuronal tissue. DDR-TRK-1N is the negative control compound.
DDR-TRK-1 (DDR1 inhibitor 6j) Preparation Products And Raw materials
Raw materials
Preparation Products
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