ChemicalBook > CAS DataBase List > I-191 (I191)

I-191 (I191)

Product Name: I-191 (I191)
CAS No.: 1690172-25-8
Chemical Name: I-191 (I191)
Synonyms: I-191;I-191 ，E0102;I-191 (I191);I-191, 10 mM in DMSO;I-191,Inhibitor,I191,inhibit,I 191,Protease Activated Receptor (PAR),Thrombin receptors;4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one;4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one , I-191;2-Piperazinone, 4-[[8-(1,1-dimethylethyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-2-yl]carbonyl]-3,3-dimethyl-
CBNumber: CB24844884
Molecular Formula: C23H26FN5O2
Formula Weight: 423.48
MOL File: 1690172-25-8.mol

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I-191 (I191) Property

Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)|
pka: 13.69±0.40(Predicted)
form: Solid
color: White to gray
Water Solubility: Water : < 0.1 mg/mL (insoluble)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0068081
Product name: I-191
Purity: 98.02%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0068081
Product name: I-191
Purity: 98.02%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611302
Product name: I-191
Purity: >98%
Packaging: 100mg
Price: $1133.9
Updated: 2021/12/16

ChemScene

Product number: CS-0068081
Product name: I-191
Purity: 98.02%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611302
Product name: I-191
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

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I-191 (I191) Chemical Properties,Usage,Production

Uses

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

IC 50

PAR2

References

[1] Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364(2):246-257. DOI:10.1124/jpet.117.245027

I-191 (I191) Preparation Products And Raw materials

Raw materials

Preparation Products

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I-191 (I191) Suppliers

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1690172-25-8, I-191 (I191)Related Search:

I-191 (I191)

I-191

2-Piperazinone, 4-[[8-(1,1-dimethylethyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-2-yl]carbonyl]-3,3-dimethyl-

4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one

I-191,Inhibitor,I191,inhibit,I 191,Protease Activated Receptor (PAR),Thrombin receptors

4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one , I-191

I-191, 10 mM in DMSO

I-191 ，E0102

1690172-25-8