PI3K/mTOR Inhibitor-2

Product Name: PI3K/mTOR Inhibitor-2
CAS No.: 1848242-58-9
Chemical Name: PI3K/mTOR Inhibitor-2
Synonyms: PI3K/mTOR Inhibitor-2;PI3K/mTOR Inhibitor-2 ，E2375;PI3K/mTOR Inhibitor-2, 10 mM in DMSO;N-(5-(3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide;Benzenesulfonamide, N-[5-(3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluoro-;PI3K,inhibit,PI3K/mTOR Inhibitor-2,Inhibitor,mTOR,PI-3K/mTOR Inhibitor-2,PI3K/mTOR Inhibitor2,PI3K/mTOR Inhibitor 2,Mammalian target of Rapamycin,Phosphoinositide 3-kinase
CBNumber: CB24845043
Molecular Formula: C20H13ClF2N4O4S
Formula Weight: 478.86
MOL File: 1848242-58-9.mol

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PI3K/mTOR Inhibitor-2 Property

Boiling point:: 609.4±65.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
pka: 6.38±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0042282
Product name: PI3K/mTORInhibitor-2
Purity: 99.45%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0042282
Product name: PI3K/mTORInhibitor-2
Purity: 99.45%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0042282
Product name: PI3K/mTORInhibitor-2
Purity: 99.45%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0042282
Product name: PI3K/mTORInhibitor-2
Purity: 99.45%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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PI3K/mTOR Inhibitor-2 Chemical Properties,Usage,Production

Uses

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

IC 50

PI3Kα: 3.4 nM (IC₅₀); PI3Kβ: 34 nM (IC₅₀); PI3Kδ: 16 nM (IC₅₀); PI3Kγ: 1 nM (IC₅₀); mTOR: 4.7 nM (IC₅₀)

References

[1] Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261. DOI:10.1021/acsmedchemlett.8b00002

PI3K/mTOR Inhibitor-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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PI3K/mTOR Inhibitor-2 Suppliers

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1848242-58-9, PI3K/mTOR Inhibitor-2Related Search:

PI3K/mTOR Inhibitor-2

Benzenesulfonamide, N-[5-(3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluoro-

PI3K,inhibit,PI3K/mTOR Inhibitor-2,Inhibitor,mTOR,PI-3K/mTOR Inhibitor-2,PI3K/mTOR Inhibitor2,PI3K/mTOR Inhibitor 2,Mammalian target of Rapamycin,Phosphoinositide 3-kinase

N-(5-(3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

PI3K/mTOR Inhibitor-2, 10 mM in DMSO

PI3K/mTOR Inhibitor-2 ，E2375

1848242-58-9

C20H13ClF2N4O4S