2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
- Product Name
- 2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
- CAS No.
- 1256341-22-6
- Chemical Name
- 2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
- Synonyms
- CX08005;CX08005,CX-08005;CX08005 >=98% (HPLC);2-{[2-(tetradecyloxy)phenyl]carbamoyl}benzoic acid;2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid;Benzoic acid, 2-[[[2-(tetradecyloxy)phenyl]amino]carbonyl]-
- CBNumber
- CB24902690
- Molecular Formula
- C28H39NO4
- Formula Weight
- 453.61
- MOL File
- 1256341-22-6.mol
2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- powder
- color
- white to beige
- InChIKey
- WOEDXTWDPRNPMZ-UHFFFAOYSA-N
- SMILES
- O=C(O)C1=C(C(NC2=C(OCCCCCCCCCCCCCC)C=CC=C2)=O)C=CC=C1
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- SML1739
- Product name
- CX08005
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $106
- Updated
- 2026/04/30
- Product number
- 42730
- Product name
- CX-08005
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2026/04/30
- Product number
- 42730
- Product name
- CX-08005
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2026/04/30
- Product number
- 42730
- Product name
- CX-08005
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $165
- Updated
- 2026/04/30
- Product number
- 42730
- Product name
- CX-08005
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $345
- Updated
- 2026/04/30
2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid Chemical Properties,Usage,Production
Uses
CX08005 is a competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
Biological Activity
CX08005 is a cell-permeable benzoic acid based compound, potent and substrate-competitive PTP1B/TCPTP dual inhibitor with anti-diabetic efficacy both in vitro and in vivo. CX08005 targets protein tyrosine phosphatase 1B (PTP1B) catalytic P-loop and acts as a substrate-competitive inhibitor against PTP1B and TCPTP (IC50 = 781 and 475 nM, respectively) with much reduced potency toward LAR, SHP1, and VHR (by 52%, 89%, and 60%, respectively, at 10 μM). CX08005 enhances insulin-dependent cellular signaling (Eff. conc. 10 nM; HepG2 cells) and glucose uptake (Eff. conc. 100-500 nM; 3T3-L1 adipocityes and C2C12 myoblasts) in vitro, as well as improves glucose tolerance and insulin sensitivity in diet-induced obesity (DIO) mice and KKAy type 2 diabetes mice (50-200 mg/kg/day i.p.) in vivo with good pharmacokinetics in SD rats (Cmax = 7425.9 ng/mL, Tmax = 6.67 h, t1/2 = 2.5 h).
storage
Store at +4°C
2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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