ChemicalBook > CAS DataBase List > BAY-293

BAY-293

Product Name
BAY-293
CAS No.
2244904-70-7
Chemical Name
BAY-293
Synonyms
BAY-293;BAY-293;BAY 293;BAY293;BAY-293, 10 mM in DMSO;Inhibitor,BAY-293,BAY293,inhibit,BAY 293,Ras;6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-(methylaminomethyl)phenyl]-2-thienyl]ethyl]quinazolin-4-amine;4-Quinazolinamine, 6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-;(R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine;(R)-(6,7-Dimethoxy-2-methyl-quinazolin-4-yl)-[1-[4-(2-methylaminomethyl-phenyl)-thiophen-2-yl]-ethyl]-amine
CBNumber
CB24904205
Molecular Formula
C25H28N4O2S
Formula Weight
448.58
MOL File
2244904-70-7.mol
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BAY-293 Property

Boiling point:
553.4±50.0 °C(Predicted)
Density 
1.218±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO: soluble
form 
A solid
pka
9.61±0.10(Predicted)
color 
White to light yellow
optical activity
[α]/D -85.0 to -103.0°, c =1.0 in DMSO
InChIKey
WEGLOYDTDILXDA-OAHLLOKOSA-N
SMILES
N1=C2C(C=C(OC)C(OC)=C2)=C(N[C@@H](C2SC=C(C3=CC=CC=C3CNC)C=2)C)N=C1C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
6857
Product name
BAY293
Purity
≥98%(HPLC)
Packaging
5
Price
$245
Updated
2021/12/16
ChemScene
Product number
CS-0084967
Product name
BAY-293
Purity
98.03%
Packaging
5mg
Price
$230
Updated
2021/12/16
ChemScene
Product number
CS-0084967
Product name
BAY-293
Purity
98.03%
Packaging
10mg
Price
$415
Updated
2021/12/16
Axon Medchem
Product number
Axon3053
Product name
BAY-293
Purity
98%
Packaging
25mg
Price
$638
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611680
Product name
BAY-293
Purity
>98%
Packaging
100mg
Price
$1208.7
Updated
2021/12/16
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BAY-293 Chemical Properties,Usage,Production

Uses

6,7-Dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-4-quinazolinamine is an effective and selective inhibitor of SOS1, blocking RAS activation via disruption of the KRAS-SOS1 interaction without significantly targeting the EGFR receptor. Thus, it has potential use in treatment of hyperproliferative disorders.

Biological Activity

BAY-293 selectively inhibits SOS1-mediated KRAS activation (IC50 = 52 nM; 50 nM wt or G12C hKRAS & 10 nM SOS1cat) via direct SOS1 binding, blocking SOS1-KRAS interaction (IC50 = 21 nM; 10 nM hSOS1c at & 5 nM hKRAS G12C) without affecting (IC50 >20 μM) CRAF RBD-KRAS interaction, KRAS G12C activation by SOS2, Cdc42 activation by DBS, or EGFR kinase activity. BAY-293 downregulates cellular active RAS (IC50 = 200 nM/Calu-1, 410 nM/HeLa) and downstream ERK phosphorylation (K-562, 150 nM/Calu-1) with good target selectivity as assessed over 358 kinases (<37% inhibition at 1 μM) and a panel of 77 GPCRs, transporters, nuclear receptors and enzymes.

IC 50

KRAS-SOS1: 21 nM (IC50)

storage

Store at -20°C

BAY-293 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-293 Suppliers

China 72 United States 6 Global 78
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

2244904-70-7, BAY-293Related Search:


  • BAY-293
  • (R)-(6,7-Dimethoxy-2-methyl-quinazolin-4-yl)-[1-[4-(2-methylaminomethyl-phenyl)-thiophen-2-yl]-ethyl]-amine
  • BAY-293;BAY 293;BAY293
  • (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine
  • 4-Quinazolinamine, 6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-
  • 6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-(methylaminomethyl)phenyl]-2-thienyl]ethyl]quinazolin-4-amine
  • Inhibitor,BAY-293,BAY293,inhibit,BAY 293,Ras
  • BAY-293, 10 mM in DMSO
  • 2244904-70-7