RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT

Product Name: RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
CAS No.: 66983-94-6
Chemical Name: RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
Synonyms: 1-(5-O-Phosphono-β-D-ribofuranosyl)-;Ribavirin 5'-monophosphate (dilithium);Ribavirin 5'-monophosphate (lithium salt);RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT;Ribavirin 5’-Monophosphate Dilithium Salt (90%);Ribavirin 5'-Monophosphate DilithiuM Salt (90%)
CBNumber: CB2495688
Molecular Formula: C17H19Li2N4O9P
Formula Weight: 468.21
MOL File: Mol file

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RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Property

Melting point:: 220°C dec.
storage temp.: -20°C Freezer
solubility: Aqueous Acid (Slightly), Water (Slightly, Sonicated)
form: Solid
color: Off-White to Pale Beige
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21821
Product name: Ribavirin 5'-monophosphate (lithium salt)
Purity: ≥95%
Packaging: 500μg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21821
Product name: Ribavirin 5'-monophosphate (lithium salt)
Purity: ≥95%
Packaging: 1mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 21821
Product name: Ribavirin 5'-monophosphate (lithium salt)
Purity: ≥95%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

TRC

Product number: R414500
Product name: Ribavirin5’-MonophosphateDilithiumSalt(90%)
Packaging: 1mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NR04851
Product name: Ribavirin 5'-monophosphate dilithium salt
Packaging: 10mg
Price: $450
Updated: 2021/12/16

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RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Chemical Properties,Usage,Production

Description

Ribavirin 5''-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported K_i value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5''-monophosphate.

Chemical Properties

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is Solid

Uses

A metabolite of Ribavirin.

Uses

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is used as an antiviral agent

References

[1] R C WILLIS J E S D A Carson. Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1978, 75 7: 3042-3044. DOI: 10.1073/pnas.75.7.3042
[2] D G STREETER. Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1973, 70 4: 1174-1178. DOI: 10.1073/pnas.70.4.1174
[3] CLERCQ E D. Specific targets for antiviral drugs.[J]. Biochemical Journal, 1982, 205 1: 1-13. DOI: 10.1042/bj2050001
[4] J. BALZARINI. Mechanism of the potentiating effect of ribavirin on the activity of 2’,3’-dideoxyinosine against human immunodeficiency virus.[J]. The Journal of Biological Chemistry, 1991, 27 1: 21509-21514. DOI: 10.1016/s0021-9258(18)54668-8
[5] BROWNE M J. Mechanism and specificity of action of ribavirin.[J]. Antimicrobial Agents and Chemotherapy, 1979, 15 6: 747-753. DOI: 10.1128/aac.15.6.747

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Suppliers

Canada 1 China 18 India 3 United Kingdom 2 United States 6 Global 30

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66983-94-6, RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALTRelated Search:

Ribavirin

Ribavirin 5'-monophosphate (lithium salt)

1-(5-O-Phosphono-β-D-ribofuranosyl)-

Ribavirin 5'-Monophosphate DilithiuM Salt (90%)

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT

Ribavirin 5'-monophosphate (dilithium)

Ribavirin 5’-Monophosphate Dilithium Salt (90%)

66983-94-6

C8H11Li2N4O8P

Bases & Related Reagents

Carbohydrates & Derivatives

Anti-virals

Inhibitors

Intermediates & Fine Chemicals

Non-nucleoside Reverse Transcriptase

Pharmaceuticals

Metabolites & Impurities

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