DIETHYL (2-CYANOETHYL)PHOSPHONATE 95 Property

Boiling point:

110 °C/0.1 mmHg (lit.)

Density 

1.08 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.4380(lit.)

Flash point:

>230 °F

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

KI6650000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DIETHYL (2-CYANOETHYL)PHOSPHONATE 95 Chemical Properties,Usage,Production

Uses

Diethyl (2-cyanoethyl)phosphonate, is a useful reactant used in various chemical synthesis such as in synthesis of lipophilic oxoamides with activity against phospholipase A2, Triose phosphate isomerase of muscle inhibitors, and also in base-catalyzed stereospecific anti-Markovnikov addition.

Uses

Reactant for:

• Heteroatom-directed alkyl cyanation of alkynes
• Use as a fluorescent substrate for carbon-phosphorous lyase
• Microwave-assisted cleavage of phosphate, phosphonate, and phorphoramide esters
• Amination and stereoselective olefination for synthesis of HIV-1 antivirals

• Base-catalyzed stereospecific anti-Markovnikov addition reactants
• Lipophilic oxoamides with activity against phospholipase A2
• Triose phosphate isomerase of muscle inhibitors