4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&
- Product Name
- 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&
- CAS No.
- 87184-99-4
- Chemical Name
- 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&
- Synonyms
- DKSI083;DKFELEX0278;TBDMS-Bu-OH;4-tert-Butyldimethylsilyloxybutanol;4-(t-BUTYLDIMETHYLSILOXY)BUTAN-1-OL;4-(tert-butyldimethylsiloxy)-1-butanol;4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&;4-[t-Butyl(Dimethyl)Silyl] Oxybutan-1-Ol;4-tert-ButyldiMethylsiloxy-1-butanol, 97%;1-tert-ButyldiMethylsilyl-4-hydroxybutane
- CBNumber
- CB2500089
- Molecular Formula
- C10H24O2Si
- Formula Weight
- 204.38
- MOL File
- 87184-99-4.mol
4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& Property
- Boiling point:
- 63-66 °C/0.3 mmHg (lit.)
- Density
- 0.888 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.4390(lit.)
- Flash point:
- 222 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Dichloromethane, Ethyl Acetate, Methanol
- form
- Oil
- pka
- 15.07±0.10(Predicted)
- Specific Gravity
- 0.888
- color
- Colourless
- Water Solubility
- Slightly Soluble in water.(2.0 g/L) (25°C). Soluble in Dichloromethane, Ethyl Acetate, Methanol
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- InChI
- InChI=1S/C10H24O2Si/c1-10(2,3)13(4,5)12-9-7-6-8-11/h11H,6-9H2,1-5H3
- InChIKey
- IJEMXJANZPVITP-UHFFFAOYSA-N
- SMILES
- C(O)CCCO[Si](C(C)(C)C)(C)C
Safety
- WGK Germany
- 3
- Storage Class
- 10 - Combustible liquids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 568589
- Product name
- 4-(tert-Butyldimethylsilyl)oxy-1-butanol
- Purity
- 97%
- Packaging
- 5g
- Price
- $50.3
- Updated
- 2022/05/15
- Product number
- D468260
- Product name
- 4-(Dimethyl-tert-Butylsilyloxy)butan-1-ol
- Packaging
- 10g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- FD22408
- Product name
- 4-(Dimethyl-tert-butylsilyloxy)butan-1-ol
- Packaging
- 50g
- Price
- $480
- Updated
- 2021/12/16
- Product number
- FD22408
- Product name
- 4-(Dimethyl-tert-butylsilyloxy)butan-1-ol
- Packaging
- 10g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FD22408
- Product name
- 4-(Dimethyl-tert-butylsilyloxy)butan-1-ol
- Packaging
- 25g
- Price
- $300
- Updated
- 2021/12/16
4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& Chemical Properties,Usage,Production
Chemical Properties
Colourless Oil
Uses
4-(Dimethyl-tert-Butylsilyloxy)butan-1-ol (cas# 87184-99-4) is a compound useful in organic synthesis.
Synthesis
110-63-4
18162-48-6
87184-99-4
To a stirred solution of 1,4-butanediol (3 mL, 33.3 mmol) in anhydrous dichloromethane (30 mL) was added imidazole (2.73 g, 66.6 mmol) at 0 °C and the mixture was stirred for 30 min. Subsequently, tert-butyldimethylchlorosilane (TBSCl, 5 g, 33.3 mmol) dissolved in dichloromethane (20 mL) was added and the mixture was stirred at room temperature for 1 hour (the progress of the reaction was monitored by TLC). Upon completion of the reaction, the reaction mixture was quenched with saturated sodium bicarbonate solution. Next, it was washed with ammonium chloride solution and extracted with dichloromethane (2 x 30 mL). The organic extracts were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. Finally, the residue was purified by column chromatography (silica gel, ethyl acetate-hexane, 2:8) to afford 4-((tert-butyldimethylsilyl)oxy)butan-1-ol (TBS ether) as a colorless slurry; yield: 6.4 g (95%).
References
[1] Journal of Organic Chemistry, 2005, vol. 70, # 16, p. 6321 - 6329
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 40, p. 9554 - 9559
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 23, p. 3362 - 3372
[4] Tetrahedron, 2003, vol. 59, # 6, p. 833 - 839
[5] Journal of Organic Chemistry, 2004, vol. 69, # 19, p. 6419 - 6426
4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& manufacturers
- Product
- 4-tert-Butyldimethylsiloxy-1-butanol 87184-99-4
- Price
- US $1.10-9.90/kg
- Min. Order
- 100kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& 87184-99-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200KG
- Release date
- 2019-08-30