4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE Property

Melting point:

19-21 °C(lit.)

Boiling point:

203 °C(lit.)

Density 

1.391 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.528(lit.)

Flash point:

189 °F

storage temp. 

2-8°C

pka

5.56±0.23(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Yellow to Orange

FreezingPoint 

20.0 to 22.0 ℃

BRN 

168085

InChIKey

OWLPCALGCHDBCN-UHFFFAOYSA-N

CAS DataBase Reference

326-90-9(CAS DataBase Reference)

EPA Substance Registry System

1,3-Butanedione, 4,4,4-trifluoro-1-(2-furanyl)- (326-90-9)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29321900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

• As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).
• As reagent in the multistep synthesis of [¹³CD₂]benzylamine.
• As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.
• In the efficient syntheses of perfluoroalkyl substituted azoles.
• Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.

General Description

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated. Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria. Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated. The conformational analysis of the enol and keto form of FTFA has been reported.