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GRP94

Product Name
GRP94
CAS No.
2234897-35-7
Chemical Name
GRP94
Synonyms
GRP94;Grp94 Inhibitor-1;Grp94 Inhibitor-1, 10 mM in DMSO;rel-4-(((1R,4R)-4-hydroxycyclohexyl)amino)-4'-isopropyl-[1,1'-biphenyl]-3-carboxamide;[1,1'-Biphenyl]-3-carboxamide, 4-[(trans-4-hydroxycyclohexyl)amino]-4'-(1-methylethyl)-;HSP,Heat shock proteins,integrin αL,Inhibitor,inhibit,integrin α2,Grp-94 Inhibitor-1,Grp94 Inhibitor 1,Grp94 Inhibitor1,Grp94 Inhibitor-1,Grp94
CBNumber
CB25006001
Molecular Formula
C22H28N2O2
Formula Weight
352.47
MOL File
2234897-35-7.mol
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GRP94 Property

Boiling point:
532.5±50.0 °C(Predicted)
Density 
1.165±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (709.28 mM; Need ultrasonic)
pka
15.08±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0067933
Product name
Grp94Inhibitor-1
Purity
99.18%
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0067933
Product name
Grp94Inhibitor-1
Purity
99.18%
Packaging
10mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-0067933
Product name
Grp94Inhibitor-1
Purity
99.18%
Packaging
50mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-0067933
Product name
Grp94Inhibitor-1
Purity
99.18%
Packaging
100mg
Price
$410
Updated
2021/12/16
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GRP94 Chemical Properties,Usage,Production

Uses

Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1].

in vivo

Grp94 Inhibitor-1 (intraperitoneal injection,qid.; coadminbistration 10 mg/kg or 30 mg/kg; 8 days) does not attenuate the colon shortening, but decreases disease activity index (DAI) scores. It also TNFα and IL-6 levels in the serum and colonic tissues and significantly reduces the p65 expression in colonic tissues, especially those in the 30 mg/kg dose group[1].

Animal Model:C57BL/6 mice (male, 20-22 g)[1]
Dosage:10 mg/kg or 30 mg/kg
Administration:Intraperitoneal injection,qid.; coadminbistration 10 mg/kg or 30 mg/kg
Result:Decreased disease activity index (DAI) scores in UC mices.

IC 50

GRP94: 2 nM (IC50)

References

[1] Jiang F, et al. Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis. J Med Chem. 2018 Nov 8;61(21):9513-9533. DOI:10.1021/acs.jmedchem.8b00800

GRP94 Preparation Products And Raw materials

Raw materials

Preparation Products

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GRP94 Suppliers

China 42 United States 4 Global 46
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
Bejing Famous Pharmaceutical Technology Co., Ltd.
Tel
13331045123
Fax
86-10-80339217
Email
2559355526@qq.com
Country
China
ProdList
14193
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1010
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58

2234897-35-7, GRP94Related Search:


  • GRP94
  • Grp94 Inhibitor-1
  • [1,1'-Biphenyl]-3-carboxamide, 4-[(trans-4-hydroxycyclohexyl)amino]-4'-(1-methylethyl)-
  • HSP,Heat shock proteins,integrin αL,Inhibitor,inhibit,integrin α2,Grp-94 Inhibitor-1,Grp94 Inhibitor 1,Grp94 Inhibitor1,Grp94 Inhibitor-1,Grp94
  • rel-4-(((1R,4R)-4-hydroxycyclohexyl)amino)-4'-isopropyl-[1,1'-biphenyl]-3-carboxamide
  • Grp94 Inhibitor-1, 10 mM in DMSO
  • 2234897-35-7