Ciproxifan

ChemicalBook > CAS DataBase List > Ciproxifan

Product Name: Ciproxifan
CAS No.: 184025-18-1
Chemical Name: Ciproxifan
Synonyms: CS-757;FUB 359;Ciproxifan, >=99%;Ciproxifan USP/EP/BP;Ciproxifan (FUB-359);Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;Methanone, cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-;Methanone, cyclopropyl[4-[3-(1H-iMidazol-4-yl)propoxy]phenyl]-
CBNumber: CB2503297
Molecular Formula: C16H18N2O2
Formula Weight: 270.33
MOL File: 184025-18-1.mol

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Ciproxifan Property

Boiling point:: 526.9±35.0 °C(Predicted)
Density: 1.231
storage temp.: 2-8°C
solubility: H₂O: insoluble
form: solid
pka: 14.54±0.10(Predicted)
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37/39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0000417
Product name: CIPROXIFAN
Purity: 95.00%
Packaging: 5MG
Price: $501.17
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180766
Product name: Ciproxifan (FUB-359)
Purity: >98%
Packaging: 100mg
Price: $615.4
Updated: 2021/12/16

ApexBio Technology

Product number: B1570
Product name: Ciproxifan
Packaging: 50mg
Price: $756
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180766
Product name: Ciproxifan (FUB-359)
Purity: >98%
Packaging: 250mg
Price: $1208.7
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180766
Product name: Ciproxifan (FUB-359)
Purity: >98%
Packaging: 1g
Price: $2395.3
Updated: 2021/12/16

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Ciproxifan Chemical Properties,Usage,Production

Definition

ChEBI: Cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone is an aromatic ketone.

Biological Activity

ciproxifan is a novel and potent antagonist of histamine h3-receptor with a ic50 value of 9.2±1.8nm [1].ciproxifan has shown the in-vitro antagonistic action to h3-receptor with a ic50 value of 9.2±1.8nm. in addition, ciproxifan has been reported to competitively antagonize the (r) α-meha induced relaxation of electrically stimulated guinea pig ileum longitudinal muscle. besides, ciproxifan has been revealed to have the effect on [125i]iodoproxyfan binding with a ki value of 0.7±0.2 nm. apart from these, ciproxifan has been found to be a selective antagonist with pki values of 9.3, 4.9, 4.6, 5.5, 5.4, 4.9, <5.0, 4.8, <5.5 and <5.7 for h3, h2, h1, muscarinic m3, adrenergic α1d, β1, serotonin 5-ht1b, 5-ht2a, 5-ht3 and 5-ht4, respectively [1].

in vitro

Ciproxifan inhibits [³H]HA release from synaptosomes with K_i of 0.5 nM. It inhibits the binding of [¹²⁵I]iodoproxyfan at the brain H3 receptor with K_i of 0.7 nM. It displays high affinity at H₃ receptor but shows low apparent affinity at other receptor subtypes as evaluated in functional tests on isolated organs ( histamine H₁ and H₂, muscarinic M₃, adrenergic α_1D and β_{1, serotonin 5-HT_1B, 5-HT_2A, 5-HT₃ and 5-HT₄ >).}

in vivo

Ciproxifan intravenously injected at dose of 1 mg/kg decreases the H₃-receptor ligand concentration in serum in Male Swiss mice, with half-times of distribution phase of 13 min and elimination phase of 87 min, respectively. Ciproxifan (1 mg/kg, po) rises brain t-MeHA level rapidly in Male Swiss mice, being already significantly increased after 30 min, reaching a plateau between 90 and 180 min and still remaining enhanced after 270 min. It leads to ED50 values of 0.23 mg/kg in cerebral cortex, 0.28 mg/kg in striatum and 0.30 mg/kg in hypothalamus in Male Wistar rats. It (3 mg/kg, ip) significantly increased choice accuracy as evaluated in the five-choice task performed using a short stimulus duration. Ciproxifan (0.15-2 mg/kg, po) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats. Ciproxifan (10 mg/kg ip) enhances prepulse inhibition in the DBA/2 strain mice. It (3 mg/kg ip) alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Ciproxifan (3 mg/kg ip) improves accuracy and decreased impulsivity in adult male hooded Lister rats.

References

[1] ligneau x1, lin j, vanni-mercier g, jouvet m, muir jl, ganellin cr, stark h, elz s, schunack w, schwartz j. neurochemical and behavioral effects of ciproxifan, a potent histamine h3-receptor antagonist. j pharmacol exp ther. 1998 nov; 287(2):658-66.

Ciproxifan Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ciproxifan manufacturers

Career Henan Chemical Co

Product: Ciproxifan 184025-18-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

184025-18-1, CiproxifanRelated Search:

CS-757

Ciproxifan (FUB-359)

Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone

FUB 359

Methanone, cyclopropyl[4-[3-(1H-iMidazol-4-yl)propoxy]phenyl]-

Ciproxifan, >=99%

Methanone, cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-

Ciproxifan USP/EP/BP

184025-18-1

Inhibitors