ChemicalBook > CAS DataBase List > HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- Product Name
- HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- CAS No.
- 29400-42-8
- Chemical Name
- HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- Synonyms
- fumigacin;Helvolic acid, Mycotoxin;Helvolic acid (Fumigacin);HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS;6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-beta)--alph;17(20),24-trien-21-oicacid,6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-(4;(8α,9β,13α,14β,17Z)-6β,16β-Diacetoxy-3,7-dioxo-29-nor-5α-dammara-1,17(20),24-trien-21-oic acid;(8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;(4α,8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid;29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4α,6β,8α,9β,13α,14β,16β,17Z)-
- CBNumber
- CB2503570
- Molecular Formula
- C33H44O8
- Formula Weight
- 568.7
- MOL File
- 29400-42-8.mol
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HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Property
- Melting point:
- 215°
- alpha
- D25 -121° (chloroform)
- Boiling point:
- 552.56°C (rough estimate)
- Density
- 1.1062 (rough estimate)
- refractive index
- 1.4900 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) - form
- A crystalline solid
- pka
- 4.05±0.41(Predicted)
- color
- White to off-white
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Safety
- RTECS
- RC1370000
- HS Code
- 29419000
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21580
- Product name
- Helvolic Acid
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $72
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21580
- Product name
- Helvolic Acid
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $231
- Updated
- 2024/03/01
TRC
- Product number
- H235125
- Product name
- HelvolicAcid
- Packaging
- 50mg
- Price
- $3090
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIBR1050
- Product name
- Helvolicacid
- Packaging
- 5mg
- Price
- $435
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIBR1050
- Product name
- Helvolicacid
- Packaging
- 1mg
- Price
- $109
- Updated
- 2021/12/16
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HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Chemical Properties,Usage,Production
Description
Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.
Uses
Helvolic acid is a mycotoxin with antibacterial activity.
Definition
ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Preparation Products And Raw materials
Raw materials
Preparation Products
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