MRS-1191

Product Name: MRS-1191
CAS No.: 185222-90-6
Chemical Name: MRS-1191
Synonyms: MRS 1191 solid;MRS1191,MRS 1191;MRS-1191 \ A3 ADENODINE RECEPTOR ANTAGON IST;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-methyl-6-phenyl-4-(2-phenylethynyl)-, 3-ethyl 5-(phenylmethyl) ester
CBNumber: CB2503828
Molecular Formula: C31H27NO4
Formula Weight: 477.55
MOL File: 185222-90-6.mol

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MRS-1191 Property

Boiling point:: 643.1±55.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10 mg/mL
form: solid
pka: 1.54±0.70(Predicted)
color: white
Stability:: Light Sensitive
InChI: 1S/C31H27NO4/c1-3-35-30(33)27-22(2)32-29(25-17-11-6-12-18-25)28(26(27)20-19-23-13-7-4-8-14-23)31(34)36-21-24-15-9-5-10-16-24/h4-18,26,32H,3,21H2,1-2H3
InChIKey: SNVFDPHQAOXWJZ-UHFFFAOYSA-N
SMILES: CCOC(=O)C1=C(C)NC(c2ccccc2)=C(C1C#Cc3ccccc3)C(=O)OCc4ccccc4

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M227
Product name: MRS 1191
Purity: solid
Packaging: 2mg
Price: $296.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: M227
Product name: MRS 1191
Purity: solid
Packaging: 5mg
Price: $1111.5
Updated: 2025/07/31

TRC

Product number: M750203
Product name: MRS 1191
Packaging: 5mg
Price: $830
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM172389
Product name: MRS 1191
Packaging: 5mg
Price: $900
Updated: 2021/12/16

AK Scientific

Product number: SYN5122
Product name: MRS 1191
Packaging: 50mg
Price: $1040
Updated: 2021/12/16

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MRS-1191 Chemical Properties,Usage,Production

Uses

MRS 1191 is a 6-Phenyl-1,4-Dihydropyridine derivative as an adenoside A3 receptor antagonist.

Definition

ChEBI: Furcelleran is a cinnamate ester.

Biochem/physiol Actions

MRS 1191 is putative A3 adenosine receptor antagonist, highly selective for human A3 receptor vs human A1 receptor. MRS 1067, MRS 1191 and MRS 1220 were found to be competitive in saturation binding studies using the agonist radioligand [125I]AB-MECA at cloned human brain A3 receptors expressed in HEK-293 cells. Antagonism was demonstrated in functional assays consisting of agonist-induced inhibition of adenylate cyclase and the stimulation of binding of [35S]guanosine 5′-O-(3-thiotriphosphate) ([35S]GTP-gamma-S) to the associated G-proteins. Activation of the human A3 receptor in A3R-CHO results in markedly impaired cell cycle progression, suggesting an important role for this adenosine receptor subtype in cell cycle regulation and cell growth. Activation of adenosine A3 receptors by Cl-IBMECA (100 nM) increased the magnitude of theta-burst induced LTP (from 1.2+/-0.6% in the control solution to 25.5+/-0.8% in the presence of Cl-IBMECA) and attenuated LTD (from 30.0+/-5.5% decrease in the control solution to 13.6+/-6.6% decrease in the presence of Cl-IBMECA). The selective adenosine A3 receptor antagonist, MRS 1191 (5-10 μM), prevented the effects of Cl-IBMECA. These findings indicate a functional role for adenosine A3 receptors in the modulation of synaptic plasticity.

MRS-1191 Preparation Products And Raw materials

Raw materials

Preparation Products

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MRS-1191 Suppliers

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185222-90-6, MRS-1191Related Search:

MRS-1191 \ A3 ADENODINE RECEPTOR ANTAGON IST

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-methyl-6-phenyl-4-(2-phenylethynyl)-, 3-ethyl 5-(phenylmethyl) ester

MRS 1191 solid

MRS1191,MRS 1191

185222-90-6