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NAPHTHOQUINE PHOSPHATE

Product Name
NAPHTHOQUINE PHOSPHATE
CAS No.
173531-58-3
Chemical Name
NAPHTHOQUINE PHOSPHATE
Synonyms
NAPHTHOQUINE PHOSPHATE;Naphathoquine Phosphate;NAPHTHOQUINE PHOSPHATE USP/EP/BP;Naphthalene phosphoric acid phenol quinoline;4-[(7-Chloro-4-quinolinyl)amino]-2-[[(tert-butyl)amino]methyl]-5,6,7,8-tetrahydro-1-naphthalenol phosphate;1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt)
CBNumber
CB2517511
Molecular Formula
C24H31ClN3O5P
Formula Weight
507.95
MOL File
173531-58-3.mol
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NAPHTHOQUINE PHOSPHATE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A3641
Product name
Naphthoquinephosphate
Packaging
10mg
Price
$61
Updated
2021/12/16
ChemScene
Product number
CS-0739
Product name
Naphthoquine(phosphate)
Purity
99.71%
Packaging
10mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-0739
Product name
Naphthoquine(phosphate)
Purity
99.71%
Packaging
50mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0739
Product name
Naphthoquine(phosphate)
Purity
99.71%
Packaging
100mg
Price
$180
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611920
Product name
Naphthoquine phosphate
Packaging
50mg
Price
$229.5
Updated
2021/12/16
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NAPHTHOQUINE PHOSPHATE Chemical Properties,Usage,Production

Biological Activity

malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. naphthoquine phosphate is a antimalarial drug developed in china.

in vitro

naphthoquine phosphate showed promising antimalaria acitivities against various p. falciparum strains. moreover, previoius study highlighted that naphthoquine did not lose potency when tested against chloroquine resistant strains [1].

in vivo

in an study aiming to investigate the antimalarial activity of naphthoquine phosphate combined with artemisinine against plasmodium knowlesi in rhesus monkey, it was found that the combination of naphthoquine phosphate and artemisinine was superior to the single component and the optimum proportion in the combination is 1 : 2.5 in treating p. knowlesi infection in monkeys [2].

target

malaria

IC 50

0.1-5.2 nm for various p. falciparum strains [1]

References

[1] delves m, plouffe d, scheurer c, meister s, wittlin s, winzeler ea, sinden re, leroy d. the activities of current antimalarial drugs on the life cycle stages of plasmodium: a comparative study with human and rodent parasites. plos med. 2012;9(2):e1001169.
[2] wang jy, ding db, li gf, zhao jh. therapeutic efficacy of naphthoquine phosphate combined with artemisinine against plasmodium knowlesi. zhongguo ji sheng chong xue yu ji sheng chong bing za zhi. 2008;26(6):442-4.
[3] tun t, tint hs, lin k, kyaw tt, myint mk, khaing w, tun zw. efficacy of oral single dose therapy with artemisinin-naphthoquine phosphate in uncomplicated falciparum malaria. acta trop. 2009;111(3):275-8.

NAPHTHOQUINE PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

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NAPHTHOQUINE PHOSPHATE Suppliers

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View Lastest Price from NAPHTHOQUINE PHOSPHATE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
NAPHTHOQUINE PHOSPHATE 173531-58-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Hebei Mojin Biotechnology Co., Ltd
Product
NAPHTHOQUINE PHOSPHATE 173531-58-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-31
Dideu Industries Group Limited
Product
NAPHTHOQUINE PHOSPHATE 173531-58-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17

173531-58-3, NAPHTHOQUINE PHOSPHATERelated Search:


  • NAPHTHOQUINE PHOSPHATE
  • Naphthalene phosphoric acid phenol quinoline
  • Naphathoquine Phosphate
  • 4-[(7-Chloro-4-quinolinyl)amino]-2-[[(tert-butyl)amino]methyl]-5,6,7,8-tetrahydro-1-naphthalenol phosphate
  • NAPHTHOQUINE PHOSPHATE USP/EP/BP
  • 1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt)
  • 173531-58-3
  • C24H28ClN3O2H3O4P
  • C24H34ClN3O9P2