DT-061

Product Name: DT-061
CAS No.: 1809427-19-7
Chemical Name: DT-061
Synonyms: DT-061(SMAP);DT061,DT 061;N-((1R,2R,3S)-2-Hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide;Benzenesulfonamide, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)-
CBNumber: CB25419728
Molecular Formula: C25H23F3N2O5S
Formula Weight: 520.52
MOL File: 1809427-19-7.mol

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DT-061 Property

Boiling point:: 625.5±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (240.14 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 10.48±0.60(Predicted)
color: Off-white to light yellow
SMILES: O[C@H]1[C@@H](CCC[C@@H]1N2C3=C(OC4=C2C=CC=C4)C=CC=C3)NS(C5=CC=C(C=C5)OC(F)(F)F)(=O)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML4143
Product name: DT-061
Purity: ≥98% (HPLC)
Packaging: 1 unit
Price: $94.05
Updated: 2025/07/31

ChemScene

Product number: CS-0069645
Product name: DT-061
Purity: 99.97%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0069645
Product name: DT-061
Purity: 99.97%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0069645
Product name: DT-061
Purity: 99.97%
Packaging: 50mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-0069645
Product name: DT-061
Purity: 99.97%
Packaging: 100mg
Price: $2950
Updated: 2021/12/16

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DT-061 Chemical Properties,Usage,Production

Uses

DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1].

in vivo

DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient^[1].

Animal Model:	6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 10⁶)^[1].
Dosage:	5 mg/kg.
Administration:	Oral gavage for 4 weeks.
Result:	Showed activity in inhibiting tumor growth.

References

[1] Kauko O, et al. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. DOI:10.1126/scitranslmed.aaq1093

DT-061 Preparation Products And Raw materials

Raw materials

Preparation Products

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DT-061 Suppliers

China 34 United States 5 Global 39

Nanjing Chemlin Chemical Co., Ltd

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1809427-19-7, DT-061Related Search:

Benzenesulfonamide, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)-

DT061,DT 061

DT-061(SMAP)

N-((1R,2R,3S)-2-Hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide

1809427-19-7