LMPTP INHIBITOR 1 dihydrochloride

Product Name: LMPTP INHIBITOR 1 dihydrochloride
CAS No.: 2310135-46-5
Chemical Name: LMPTP INHIBITOR 1 dihydrochloride
Synonyms: YUN35454;LMPTP INHIBITOR 1 dihydrochloride;LMW-PTP Inhibitor I (hydrochloride);LMPTP INHIBITOR 1 dihydrochloride, 10 mM in DMSO;N,N-Diethyl-4-(4-((3-(piperidin-1-yl)propyl)amino)quinolin-2-yl)benzamide dihydrochloride;inhibit,LMPTP inhibitor-1,LMPTP inhibitor 1,LMPTP INHIBITOR 1 dihydrochloride,Phosphatase,LMPTP inhibitor1,Inhibitor
CBNumber: CB25419773
Molecular Formula: C28H37ClN4O
Formula Weight: 481.08
MOL File: 2310135-46-5.mol

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LMPTP INHIBITOR 1 dihydrochloride Property

storage temp.: Store at -20°C
solubility: DMF: 20mg/mL; DMSO: 10mg/mL; Ethanol: 15mg/mL; PBS (pH 7.2): 3mg/mL
form: A crystalline solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22277
Product name: LMW-PTP Inhibitor I (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22277
Product name: LMW-PTP Inhibitor I (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 22277
Product name: LMW-PTP Inhibitor I (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 22277
Product name: LMW-PTP Inhibitor I (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

ChemScene

Product number: CS-0045260
Product name: LMPTPINHIBITOR1dihydrochloride
Purity: 99.63%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

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LMPTP INHIBITOR 1 dihydrochloride Chemical Properties,Usage,Production

Uses

LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.

in vivo

LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight^[1].

References

[1] Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632. DOI:10.1038/nchembio.2344

LMPTP INHIBITOR 1 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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LMPTP INHIBITOR 1 dihydrochloride Suppliers

China 28 India 1 United States 5 Global 34

Shanghai EFE Biological Technology Co., Ltd.

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InvivoChem

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2310135-46-5, LMPTP INHIBITOR 1 dihydrochlorideRelated Search:

LMPTP INHIBITOR 1 dihydrochloride

inhibit,LMPTP inhibitor-1,LMPTP inhibitor 1,LMPTP INHIBITOR 1 dihydrochloride,Phosphatase,LMPTP inhibitor1,Inhibitor

LMW-PTP Inhibitor I (hydrochloride)

N,N-Diethyl-4-(4-((3-(piperidin-1-yl)propyl)amino)quinolin-2-yl)benzamide dihydrochloride

YUN35454

LMPTP INHIBITOR 1 dihydrochloride, 10 mM in DMSO

2310135-46-5