MD2-TLR4-IN-1

Product Name: MD2-TLR4-IN-1
CAS No.: 2249801-12-3
Chemical Name: MD2-TLR4-IN-1
Synonyms: MD2-TLR4-I;MD2-TLR4-IN-1;MD2-TLR4-IN-1, 10 mM in DMSO;N-(3-(1H-Indol-5-yl)-1H-indazol-5-yl)-2,6-dichlorobenzamide;Benzamide, 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]-;inhibit,Toll-like Receptor (TLR),MD2 TLR4 IN 1,MD2TLR4IN1,MD-2-TLR4-IN-1,Inhibitor
CBNumber: CB25478163
Molecular Formula: C22H14Cl2N4O
Formula Weight: 421.28
MOL File: 2249801-12-3.mol

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MD2-TLR4-IN-1 Property

storage temp.: Store at -20°C
solubility: DMSO: 83.33 mg/mL (197.80 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0096014
Product name: MD2-TLR4-IN-1
Purity: 99.69%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0096014
Product name: MD2-TLR4-IN-1
Purity: 99.69%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0096014
Product name: MD2-TLR4-IN-1
Purity: 99.69%
Packaging: 25mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0096014
Product name: MD2-TLR4-IN-1
Purity: 99.69%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0096014
Product name: MD2-TLR4-IN-1
Purity: 99.69%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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MD2-TLR4-IN-1 Chemical Properties,Usage,Production

Uses

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

References

[1] Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469. DOI:10.1021/acs.jmedchem.9b00316

MD2-TLR4-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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MD2-TLR4-IN-1 Suppliers

China 39 United States 3 Global 42

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2249801-12-3, MD2-TLR4-IN-1Related Search:

hToll

MD2-TLR4-IN-1

Benzamide, 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]-

N-(3-(1H-Indol-5-yl)-1H-indazol-5-yl)-2,6-dichlorobenzamide

inhibit,Toll-like Receptor (TLR),MD2 TLR4 IN 1,MD2TLR4IN1,MD-2-TLR4-IN-1,Inhibitor

MD2-TLR4-I

MD2-TLR4-IN-1, 10 mM in DMSO

2249801-12-3