Propargyl-PEG4-N3

Product Name: Propargyl-PEG4-N3
CAS No.: 1192590-91-2
Chemical Name: Propargyl-PEG4-N3
Synonyms: Propargyl-PEG4-N3;3,6,9,12-Tetraoxapentadec-14-yne, 1-azido-
CBNumber: CB25478239
Molecular Formula: C11H19N3O4
Formula Weight: 257.29
MOL File: 1192590-91-2.mol

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Hazard and Precautionary Statements (GHS)

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Propargyl-PEG4-N3 Chemical Properties,Usage,Production

Uses

Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Biological Activity

Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG4-N3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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View Lastest Price from Propargyl-PEG4-N3 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG4-N3 1192590-91-2
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-26

1192590-91-2, Propargyl-PEG4-N3Related Search:

H2N-PEG4-Propyne Propargyl-PEG4-NHS ester Propargyl-PEG4-t-butyl ester

Propargyl-PEG4-N3

3,6,9,12-Tetraoxapentadec-14-yne, 1-azido-

1192590-91-2