ChemicalBook > CAS DataBase List > FLT3-IN-3
FLT3-IN-3
- Product Name
- FLT3-IN-3
- CAS No.
- 2229050-90-0
- Chemical Name
- FLT3-IN-3
- Synonyms
- SAN50900;FLT3-IN-3;FLT3-IN-3, 10 mM in DMSO;N2-(trans-4-Aminocyclohexyl)-9-cyclopentyl-N6-(4-(morpholinomethyl)phenyl)-9H-purine-2,6-diamine;9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-;9-cyclopentyl-N6-{4-[(morpholin-4-yl)methyl]phenyl}-N2-[(1r,4r)-4-aminocyclohexyl]-9H-purine-2,6-diamine;inhibit,Fms like tyrosine kinase 3,FLT-3-IN-3,FLT3,CD135,Inhibitor,Cluster of differentiation antigen 135,FLT3IN3,FLT3 IN 3
- CBNumber
- CB25540576
- Molecular Formula
- C27H38N8O
- Formula Weight
- 490.64
- MOL File
- 2229050-90-0.mol
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FLT3-IN-3 Property
- Boiling point:
- 717.6±70.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): insol
- form
- A solid
- pka
- 10.42±0.70(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0043484
- Product name
- FLT3-IN-3
- Purity
- 99.73%
- Packaging
- 5mg
- Price
- $400
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC44219
- Product name
- FLT3-IN-3
- Purity
- >98%
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
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FLT3-IN-3 Chemical Properties,Usage,Production
Uses
FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.
in vivo
A single dose of FLT3-IN-3 (Compound 7d; 10 mg/kg; i.p.) in mice with subcutaneous MV4-11 xenografts causes sustained inhibition of FLT3 and STAT5 phosphorylation over 48 hours[1].
| Animal Model: | Female athymic nu/nu mice with subcutaneously implanted MV4-11 xenografts[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal (i.p.) injection; 48 hours |
| Result: | Effectively inhibited FLT3-ITD autophosphorylation in MV4-11 xenografts. |
References
[1] Gucky T, et al. Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61(9):3855-3869. DOI:10.1021/acs.jmedchem.7b01529
FLT3-IN-3 Preparation Products And Raw materials
Raw materials
Preparation Products
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