Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl-

Product Name: Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl-
CAS No.: 1396814-79-1
Chemical Name: Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl-
Synonyms: VU0542270;VU 0542270 New;Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl-;1-((4-Methyl-2-(thiophen-2-yl)thiazol-5-yl)methyl)-3-(thiophen-2-yl)urea
CBNumber: CB25553989
Molecular Formula: C14H13N3OS3
Formula Weight: 335.47
MOL File: 1396814-79-1.mol

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Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl- Property

Density: 1.425±0.06 g/cm3(Predicted)
solubility: DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml
pka: 12.55±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl- Chemical Properties,Usage,Production

Description

VU0542270 is an inhibitor of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.1 (SUR2B/Kir6.1; IC50 = 0.11 µM).1 It is selective for SUR2B/Kir6.1 over ten other inward-rectifier potassium channels (Kirs; IC50s = >30 µM for all). VU0542270 (10 or 100 µM) induces constriction in isolated mouse ductus arteriosus vessels.WARNING This product is not for human or veterinary use.

References

[1] LI K, MCCLENAHAN S J, HAN C, et al. Discovery and characterization of VU0542270, the first selective inhibitor of vascular Kir6.1/SUR2B KATPchannels[J]. Molecular Pharmacology, 2024, 14 1. DOI: 10.1124/molpharm.123.000783

Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl- Suppliers

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1396814-79-1, Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl-Related Search:

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Urea, N-[[4-methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N'-2-thienyl-

VU0542270

1-((4-Methyl-2-(thiophen-2-yl)thiazol-5-yl)methyl)-3-(thiophen-2-yl)urea

VU 0542270 New

1396814-79-1

C14H13N3OS3