ChemicalBook > CAS DataBase List > BI-3406

BI-3406

Product Name: BI-3406
CAS No.: 2230836-55-0
Chemical Name: BI-3406
Synonyms: N-((R)-1-(3-Amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine;BI-3406;SOS1-IN-2;BI-3406 ，S8916;BI-3406(SOS1-IN-2);N-[(1R)-1-[3-Amino-5-;BI-3406, 10 mM in DMSO;N-[(1R)-1-[3-Amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine;KRAS,interaction,anticancer,Inhibitor,BI3406,BI 3406,inhibit,Son,Sevenless,GTP-loaded,BI-3406,Ras,p38 MAPK,orally,SOS1;N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-4-amine
CBNumber: CB25559774
Molecular Formula: C23H25F3N4O3
Formula Weight: 462.46
MOL File: 2230836-55-0.mol

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BI-3406 Property

Boiling point:: 534.5±50.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);216.23(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);216.23(Max Conc. mM)
form: A solid
pka: 6.58±0.70(Predicted)
color: White to off-white
InChIKey: XVFDNRYZXDHTHT-PXAZEXFGSA-N
SMILES: N1=C2C(C=C(O[C@H]3CCOC3)C(OC)=C2)=C(N[C@@H](C2=CC(C(F)(F)F)=CC(N)=C2)C)N=C1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0100048
Product name: BI-3406
Purity: 99.79%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0100048
Product name: BI-3406
Purity: 99.79%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0100048
Product name: BI-3406
Purity: 99.79%
Packaging: 50mg
Price: $2000
Updated: 2021/12/16

ChemScene

Product number: CS-0100048
Product name: BI-3406
Purity: 99.79%
Packaging: 100mg
Price: $3500
Updated: 2021/12/16

DC Chemicals

Product number: DC39083
Product name: BI-3406
Packaging: 100mg
Price: $900
Updated: 2021/12/16

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BI-3406 Chemical Properties,Usage,Production

Uses

BI-3406 (compound I-6) is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity[1][2].

IC 50

KRAS-SOS1: 6 nM (IC₅₀)

References

[1] Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.
[2] Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.

BI-3406 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-3406 Suppliers

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2230836-55-0, BI-3406Related Search:

BI-2852 RMC-9805 RMC-7977 2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- MRTX1133 BI-2493 BI-2865 Adagrasib

BI-3406

SOS1-IN-2

N-((R)-1-(3-Amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine

4-Quinazolinamine, N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[[(3S)-tetrahydro-3-furanyl]oxy]-

N-[(1R)-1-[3-Amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine

N-[(1R)-1-[3-Amino-5-

KRAS,interaction,anticancer,Inhibitor,BI3406,BI 3406,inhibit,Son,Sevenless,GTP-loaded,BI-3406,Ras,p38 MAPK,orally,SOS1

N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-4-amine

BI-3406(SOS1-IN-2)

BI-3406, 10 mM in DMSO

BI-3406 ，S8916

2230836-55-0

APIs

API