TK216

Product Name: TK216
CAS No.: 1903783-48-1
Chemical Name: TK216
Synonyms: TK216;TK216, 10 mM in DMSO;4,7-dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one;4,7-Dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-1,3-dihydro-3-hydroxy-2H-indol-2-one;2H-Indol-2-one, 4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-1,3-dihydro-3-hydroxy-;Inhibitor,EWS-FLI1,DNA/RNA Synthesis,transcription,TK-216,TK216,RNA,proliferation,EST,inhibit,sarcoma,anticancer,TK 216,leukemia,Ewing,virus,E26,Friend
CBNumber: CB25821190
Molecular Formula: C19H15Cl2NO3
Formula Weight: 376.23
MOL File: 1903783-48-1.mol

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TK216 Property

Boiling point:: 614.0±55.0 °C(Predicted)
Density: 1.473±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 250 mg/mL (664.49 mM)
pka: 10.40±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090240
Product name: TK216
Purity: 99.66%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0090240
Product name: TK216
Purity: 99.66%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0090240
Product name: TK216
Purity: 99.66%
Packaging: 25mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0090240
Product name: TK216
Purity: 99.66%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0090240
Product name: TK216
Purity: 99.66%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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TK216 Chemical Properties,Usage,Production

Uses

TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2].

in vivo

TK216 (po; 100 mg/kg; twice daily for 13 days) results in tumor growth inhibition of the TMD-8 xenograft model^[1].

Animal Model:	NOD-Scid mice subcutaneously inoculated with TMD8 cells^[1]
Dosage:	100 mg/kg
Administration:	PO; twice daily for 13 days
Result:	Resulted in tumor growth inhibition.

References

[1] Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176. DOI:10.1158/1078-0432.CCR-18-2718
[2] Brian Lannutti, et al. Uses of indolinone compounds. US10159660B2.

TK216 Preparation Products And Raw materials

Raw materials

Preparation Products

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TK216 Suppliers

China 36 United States 3 Global 39

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
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Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
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Shanghai Taifu Pharmaceutical Technology Co. LTD

Tel: 021-58111238 18930958102
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Email: sales@taifupharm.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.

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Fax: QQ:3008007432
Email: 3008007409@qq.com
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Tianjin Kailiqi Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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Email: liming@bio-fount.com
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Taizhou Crene Biotechnology Co. Ltd.

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Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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1903783-48-1, TK216Related Search:

TK216

4,7-dichloro-3-(2-(4-cyclopropylphenyl)-2-oxoethyl)-3-hydroxyindolin-2-one

2H-Indol-2-one, 4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-1,3-dihydro-3-hydroxy-

4,7-Dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-1,3-dihydro-3-hydroxy-2H-indol-2-one

Inhibitor,EWS-FLI1,DNA/RNA Synthesis,transcription,TK-216,TK216,RNA,proliferation,EST,inhibit,sarcoma,anticancer,TK 216,leukemia,Ewing,virus,E26,Friend

TK216, 10 mM in DMSO

1903783-48-1