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MYCi361

Product Name
MYCi361
CAS No.
2289690-31-7
Chemical Name
MYCi361
Synonyms
MYCi361;NUCC-0196361;MYCi361 ，S8905;MYCi361 (NUCC-0196361);c-Myc,NUCC0196361,MYCi 361,MYCi361,MYCi-361,NUCC 0196361,inhibit,Inhibitor,Myc;2-[3,5-bis(trifluoromethyl)phenyl]-3-[(4-chlorophenyl)methoxy]-6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]phenol;6-((4-Chlorobenzyl)oxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-2-ol;[1,1'-Biphenyl]-2-ol, 6-[(4-chlorophenyl)methoxy]-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3',5'-bis(trifluoromethyl)-
CBNumber
CB25821226
Molecular Formula
C26H16ClF9N2O2
Formula Weight
594.86
MOL File
2289690-31-7.mol
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MYCi361 Property

storage temp. 
2-8°C
solubility 
Soluble in DMSO:110.0(Max Conc. mg/mL);184.9(Max Conc. mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC32581
Product name
MYCi361
Packaging
100mg
Price
$700
Updated
2021/12/16
DC Chemicals
Product number
DC32581
Product name
MYCi361
Packaging
250mg
Price
$1150
Updated
2021/12/16
DC Chemicals
Product number
DC32581
Product name
MYCi361
Packaging
1g
Price
$2500
Updated
2021/12/16
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MYCi361 Chemical Properties,Usage,Production

Uses

MYCi361 (NUCC-0196361) is a MYC inhibitor with the Kd of 3.2 μM for binding to MYC. MYCi361 (NUCC-0196361) suppresses tumor growth and enhances anti-PD1 immunotherapy[1].

in vivo

MYCi361 inhibits MYC-dependent tumor growth in vivo. MYCi361 treatment (100 mg/kg/day for 2 days; then 70 mg/kg/day for 9 days) induces tumor regression in FVB or NSG male mice[1].
MYCi361 has moderate terminal elimination half-life of 44 and 20 h for intraperitoneal (i.p.) or oral (p.o.) dosing in mice, respectively[1].
MYCi361 suppresses tumor growth in mice, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy. However, MYCi361 demonstrates a narrow therapeutic index. An improved analog, MYCi975 shows better tolerability[1].

Animal Model:FVB or NSG male mice of 6-8 weeks of age and 25 g bearing established MycCaP tumors[1]
Dosage:50 mg/kg and 70 mg/kg
Administration:Treatment i.p. initially at 50 mg/kg twice daily for 2 days, then 70 mg/kg/day for 9 days
Result:Induced tumor regression.
Animal Model:C57BL/6 mice[1]
Dosage:50 mg/kg (Pharmacokinetic analysis)
Administration:Treated p.o. or i.p.; 24 hours
Result:Intraperitoneal (i.p.) or oral (p.o.) dosing in mice indicated plasma half-lives of 44 and 20 h, respectively, with maximum plasma concentrations (Cmax) of 27,200 ng/mL (46 μM) i.p. and 13,867 ng/mL (23 μM) p.o..

References

[1] Han H, et al. Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Cancer Cell. 2019 Nov 11;36(5):483-497.e15. DOI:10.1016/j.ccell.2019.10.001

MYCi361 Preparation Products And Raw materials

Raw materials

Preparation Products

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MYCi361 Suppliers

China 51 United States 4 Global 55
Shanghai Synteam Biochem CO.,ltd
Tel
+86-021-58380978 13482386415
Fax
021-58380978
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info@systeambc.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4757
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55
Suzhou Unite pharmTech Co., Ltd ,
Tel
792-3901125 13222993784
Fax
0512-62575043
Email
sales@unite-pharm.com
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China
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56
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
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Email
info@angtibio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
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China
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71826
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
Email
2853530910@QQ.com
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China
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8000
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Shanghai SuperLan Chemcial Technique Centre
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0-2022843681 15618226720
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+86-21-51601218
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chaolaichem@foxmail.com
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China
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Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
Fax
0550-5196001
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wj520wjxby@126.com
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China
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1944
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Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
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China
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9729
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58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
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11797
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58

2289690-31-7, MYCi361Related Search:


  • MYCi361
  • NUCC-0196361
  • [1,1'-Biphenyl]-2-ol, 6-[(4-chlorophenyl)methoxy]-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3',5'-bis(trifluoromethyl)-
  • MYCi361 (NUCC-0196361)
  • 6-((4-Chlorobenzyl)oxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-2-ol
  • c-Myc,NUCC0196361,MYCi 361,MYCi361,MYCi-361,NUCC 0196361,inhibit,Inhibitor,Myc
  • 2-[3,5-bis(trifluoromethyl)phenyl]-3-[(4-chlorophenyl)methoxy]-6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]phenol
  • MYCi361 ，S8905
  • 2289690-31-7
  • C26H16ClF9N2O2