Compstatin analog peptide CP40

Product Name: Compstatin analog peptide CP40
CAS No.: 1427001-89-5
Chemical Name: Compstatin analog peptide CP40
Synonyms: AMY-101;Compstatin 40;AMY-101(Cp40);Compstatin analog peptide CP40;L-Isoleucinamide, D-tyrosyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-α-aspartyl-L-tryptophyl-N-methylglycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-N2-methyl-, cyclic (3→13)-disulfide
CBNumber: CB26124421
Molecular Formula: C83H117N23O18S2
Formula Weight: 1789.11
MOL File: 1427001-89-5.mol

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Compstatin analog peptide CP40 Property

Density: 1.46±0.1 g/cm3(Predicted)
pka: 4.00±0.10(Predicted)
Sequence: {D-Tyr}-Ile-Cys-Val-{Trp(Me)}-Gln-Asp-Trp-{Sar}-Ala-His-Arg-Cys-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0092182
Product name: AMY-101
Packaging: 1mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-0092182
Product name: AMY-101
Packaging: 5mg
Price: $980
Updated: 2021/12/16

ChemScene

Product number: CS-0092182
Product name: AMY-101
Packaging: 10mg
Price: $1650
Updated: 2021/12/16

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Compstatin analog peptide CP40 Chemical Properties,Usage,Production

Uses

AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].

in vivo

AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis^[1].
AMY-101 can induce a long-lasting anti-inflammatory effect^[1].
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction^[1].
AMY-101 (Cp40, 1 mg/kg, sc, injection every 12 h, daily, 7 or 14 days) attenuates fibrosis and infiltration of inflammatory cells in UUO-induced renal fibrosis^[3].

Animal Model:	Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight)^[1].
Dosage:	0.1 mg/site; 50 μL of 2 mg/mL solution.
Administration:	Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.)
Result:	Does not cause irritation in healthy gingiva.

Animal Model:	UUO and sham-operated mice^[3].
Dosage:	1 mg/kg.
Administration:	Subcutaneous injection every 12 h, daily, 7 or 14 days.
Result:	1 mg/kg Cp40 had much less severe interstitial fibrosis than control peptide-injected mice.

References

[1] Kajikawa T, et al. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215. DOI:10.1016/j.omtm.2017.08.001
[2] Mastaglio S, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Apr 29:108450 DOI:10.1016/j.clim.2020.108450
[3] Yanyan Liu, et al. Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion. Front Immunol. 2018 Oct 22;9:2385. DOI:10.3389/fimmu.2018.02385

Compstatin analog peptide CP40 Preparation Products And Raw materials

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Preparation Products

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Compstatin analog peptide CP40 Suppliers

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1427001-89-5, Compstatin analog peptide CP40Related Search:

Compstatin 40

Compstatin analog peptide CP40

AMY-101

L-Isoleucinamide, D-tyrosyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-α-aspartyl-L-tryptophyl-N-methylglycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-N2-methyl-, cyclic (3→13)-disulfide

AMY-101(Cp40)

1427001-89-5

C83H117N23O18S2