YP001

Product Name: YP001
CAS No.: 1192171-69-9
Chemical Name: YP001
Synonyms: YP001;PLX007;PXL007;EYP-001;Vonafexor;Vonafexor(EYP-001);Vonafexor, 10 mM in DMSO;Vonafexor(PLX007,EYP-001);NR1H4,HBV,FXR,EYP 001,Inhibitor,Vonafexor,EYP-001,inhibit,Hepatitis B virus;4-Chloro-5-(4-((2,6-dichlorophenyl)sulfonyl)piperazin-1-yl)benzofuran-2-carboxylic acid
CBNumber: CB26188533
Molecular Formula: C19H15Cl3N2O5S
Formula Weight: 489.76
MOL File: 1192171-69-9.mol

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YP001 Property

Boiling point:: 680.5±65.0 °C(Predicted)
Density: 1.604±0.06 g/cm3(Predicted)
pka: 3.05±0.30(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0119143
Product name: Vonafexor
Purity: 99.87%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0119143
Product name: Vonafexor
Purity: 99.87%
Packaging: 10mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-0119143
Product name: Vonafexor
Purity: 99.87%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0119143
Product name: Vonafexor
Purity: 99.87%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0119143
Product name: Vonafexor
Purity: 99.87%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

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YP001 Chemical Properties,Usage,Production

Uses

Vonafexor (EYP001) is an orally active, non-steroidal and selective FXR agonist. Vonafexor shows significant HBsAg reduction when combined with Peg-IFNα. Vonafexor can be used for anti-HBV research[1][2].

References

[1] Erken R, et al. Farnesoid X receptor agonist for the treatment of chronic hepatitis B: A safety study. J Viral Hepat. 2021 Dec;28(12):1690-1698. DOI:10.1111/jvh.13608
[2] Hui RW, et al. Assessing the developing pharmacotherapeutic landscape in hepatitis B treatment: a spotlight on drugs in phase II clinical trials. Expert Opin Emerg Drugs. 2022 Jun;27(2):127-140. DOI:10.1080/14728214.2022.2074977
[3] Joly S, et al. The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells. J Hepatol 66(1):S690.
[4] Fiorucci S,et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) [published online ahead of print, 2020 Jun 19]. Expert Opin Investig Drugs. 2020;1-10. DOI:10.1080/13543784.2020.1763302

YP001 Preparation Products And Raw materials

Raw materials

Preparation Products

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YP001 Suppliers

China 48 United States 4 Global 52

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4800
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2495
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9543
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10408
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29662
Advantage: 68

Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 021-61350663 15502154572
Fax: -
Email: 1639466865@qq.com
Country: China
ProdList: 499
Advantage: 58

Fujian boshi pharmaceutical technology co. LTD

Tel: 0595-22008920; 18120708884
Email: 393612455@qq.com
Country: China
ProdList: 255
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

1192171-69-9, YP001Related Search:

YP001

EYP-001

PXL007

Vonafexor

PLX007

2-Benzofurancarboxylic acid, 4-chloro-5-[4-[(2,6-dichlorophenyl)sulfonyl]-1-piperazinyl]-

Vonafexor(PLX007,EYP-001)

4-Chloro-5-(4-((2,6-dichlorophenyl)sulfonyl)piperazin-1-yl)benzofuran-2-carboxylic acid

Vonafexor(EYP-001)

NR1H4,HBV,FXR,EYP 001,Inhibitor,Vonafexor,EYP-001,inhibit,Hepatitis B virus

Vonafexor, 10 mM in DMSO

4-chloro-5-[4-(2,6-dichlorobenzene-1- sulfonyl)piperazin-1-yl]-1-benzofuran-2-carboxylic acid

4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid

1192171-69-9

C19H15Cl3N2O5S