ChemicalBook > CAS DataBase List > SEP-363856 HCl

SEP-363856 HCl

Product Name
SEP-363856 HCl
CAS No.
1310422-41-3
Chemical Name
SEP-363856 HCl
Synonyms
SEP-363856 HCl;SEP-856 hydrochloride;SEP-363856 hydrochloride;SEP-363856 HCl (Ulotaront);SEP-363856 (SEP-856) hydrochloride;SEP-363856 hydrochloride, 10 mM in DMSO;1-[(7S)-5,7-dihydro-4H-thieno[2,3-c]pyran-7-yl]-N-methylmethanamine;Inhibitor,SEP 856,SEP856,SEP363856,SEP 363856 hydrochloride,5-hydroxytryptamine Receptor,inhibit,Serotonin Receptor,SEP363856 hydrochloride,SEP-363856,SEP 363856,SEP-856,5-HT Receptor
CBNumber
CB26199351
Molecular Formula
C9H14ClNOS
Formula Weight
219.73
MOL File
1310422-41-3.mol
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SEP-363856 HCl Property

solubility 
DMSO:60.0(Max Conc. mg/mL);273.06(Max Conc. mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0119592
Product name
SEP-363856(hydrochloride)
Purity
99.78%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0119592
Product name
SEP-363856(hydrochloride)
Purity
99.78%
Packaging
10mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0119592
Product name
SEP-363856(hydrochloride)
Purity
99.78%
Packaging
50mg
Price
$1250
Updated
2021/12/16
ChemScene
Product number
CS-0119592
Product name
SEP-363856(hydrochloride)
Purity
99.78%
Packaging
100mg
Price
$1800
Updated
2021/12/16
DC Chemicals
Product number
027606
Product name
SEP-363856(hydrochloride)
Packaging
001
Price
$750
Updated
2021/12/16
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SEP-363856 HCl Chemical Properties,Usage,Production

Uses

SEP-363856 (SEP-856) hydrochloride, an orally active TAAR1 and 5-HT1A agonist and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride has the potential for the study of schizophrenia[1].

in vivo

SEP-856 (0.3, 1 and 10 mg/kg, i.p.) hydrochloride is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs[1].
SEP-856 (0.3, 1 and 10 mg/kg, orally once) hydrochloride significantly reduces PCP-induced hyperactivity[1].
Oral SEP-856 hydrochloride administration (1, 3 and 10 mg/kg) produces a dosedependent decrease in REM sleep, increase in latency to REM sleep and increase in cumulative wake (W) time[1].

Animal Model:Acute treatment with phencyclidine (PCP), which induces robust hyperactivity in rodents[1].
Dosage:0.3, 1 and 3 mg/kg.
Administration:Orally once.
Result:Resulted in a dose-dependent inhibition of PCP-induced hyperactivity responses in C57Bl/6J mice (1-way ANOVA F (5, 59) = 18.96, p < 0.0001; Tukey’s post-hoc test, p < 0.05) with a 50% effective dose (ED50) of approximately 0.3 mg/kg.
Animal Model:Male Sprague Dawley rats[1].
Dosage:1, 2, and 5 mg/kg.
Administration:I.V. injection. (Pharmacokinetic Analysis).
Result:Rapidly absorbed with maximum plasma and brain concentrations reached within 0.25 to 0.5 hours in mice and rats and maximum plasma concentrations reached within 6 ± 2.83 hours in monkeys.
Penetrated mouse and rat brains after oral administration (10 mg/kg), with average brain-to-plasma AUC ratios of ~3 respectively.

IC 50

TAAR1: 0.140 μM (EC50); 5-HT1A Receptor: 2.3 μM (EC50); 5-HT1B Receptor: 15.6 μM (EC50); 5-HT1D Receptor: 0.262 μM (EC50); 5-HT2A Receptor: >10 μM (EC50); 5-HT2C Receptor: 30 μM (EC50); 5-HT7 Receptor: 6.7 μM (EC50)

References

[1] Dedic N, et al. SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14. DOI:10.1124/jpet.119.260281

SEP-363856 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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SEP-363856 HCl Suppliers

China 34 United States 3 Global 37
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1136
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64
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097 15801866362;
Email
info@topbiochem.com
Country
China
ProdList
9520
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58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
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55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
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60
ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
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Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471;
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
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58

1310422-41-3, SEP-363856 HClRelated Search:


  • SEP-363856 HCl
  • SEP-363856 hydrochloride
  • SEP-856 hydrochloride
  • SEP-363856 (SEP-856) hydrochloride
  • Inhibitor,SEP 856,SEP856,SEP363856,SEP 363856 hydrochloride,5-hydroxytryptamine Receptor,inhibit,Serotonin Receptor,SEP363856 hydrochloride,SEP-363856,SEP 363856,SEP-856,5-HT Receptor
  • SEP-363856 HCl (Ulotaront)
  • SEP-363856 hydrochloride, 10 mM in DMSO
  • 1-[(7S)-5,7-dihydro-4H-thieno[2,3-c]pyran-7-yl]-N-methylmethanamine
  • 1310422-41-3