ChemicalBook > CAS DataBase List > 2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE

2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE

Product Name
2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE
CAS No.
1151564-03-2
Chemical Name
2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE
Synonyms
2-(2-Chloro-3-methoxyphenyl);2-Chloro-3-Methoxyphenylboronic acid pinacol ester;2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE;1,3,2-Dioxaborolane, 2-(2-chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-
CBNumber
CB2664211
Molecular Formula
C13H18BClO3
Formula Weight
268.54
MOL File
Mol file
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2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE Property

Boiling point:
356.8±32.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
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Safety

HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C427915
Product name
2-(2-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
Packaging
25mg
Price
$45
Updated
2021/12/16
TRC
Product number
C427915
Product name
2-(2-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
Packaging
250mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR360118
Product name
2-(2-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
Purity
95+%
Packaging
250mg
Price
$94
Updated
2021/12/16
SynQuest Laboratories
Product number
6660-5-42
Product name
2-(2-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane
Packaging
250mg
Price
$111
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0001453
Product name
2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE
Purity
95.00%
Packaging
250MG
Price
$228.9
Updated
2021/12/16
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2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE Chemical Properties,Usage,Production

Synthesis

1151564-17-8

77-78-1

1151564-03-2

GENERAL STEPS: To a stirred solution of 2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol (830 g, 3.26 mol) in anhydrous DMF (4.15 L) was added potassium carbonate (1126.4 g, 8.15 mol) under inert atmosphere. Dimethyl sulfate (402 mL, 4.24 mol) was slowly added dropwise to control the exothermic nature of the reaction (the dropwise addition time was controlled to be within 30 minutes, and the reaction temperature was increased from 28°C to 55°C). After the dropwise addition was completed, stirring of the reaction mixture was continued for 10 minutes. The reaction mixture was slowly poured into a stirred aqueous 2 N hydrochloric acid solution (5.98 L) to control gas release. The resulting precipitate was stirred for 2 h, filtered and washed with water (1 L). The solid was dried in a vacuum oven with a desiccant for 4 days to give 2-(2-chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (7a) as a white powder (746.7 g, 2.78 mol, 85% yield).

References

[1] Patent: WO2009/62087, 2009, A1. Location in patent: Page/Page column 23

2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE Suppliers

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1151564-03-2, 2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANERelated Search:

2-Chloro-3-methoxyphenylboronic acid 2-(3-Fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(3-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol 2-(4-(Bromomethyl)-2-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1-Phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 4-Chloro-2-methylphenylboronic acid pinacol ester 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 2-Cyano-4-(trifluoromethyl)phenylboronic acid pinacol ester

  • 2-Chloro-3-Methoxyphenylboronic acid pinacol ester
  • 2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE
  • 2-(2-Chloro-3-methoxyphenyl)
  • 1,3,2-Dioxaborolane, 2-(2-chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-
  • 1151564-03-2