1-BOC-1,7-DIAMINOHEPTANE

Product Name: 1-BOC-1,7-DIAMINOHEPTANE
CAS No.: 99733-18-3
Chemical Name: 1-BOC-1,7-DIAMINOHEPTANE
Synonyms: Boc-DAHpt;Boc-NH-(CH2)7-NH2;1-BOC-1,7-DIAMINOHEPTANE;N-Boc-1,7-Diaminoheptane;N1-BOC-1,7-DIAMINOHEPTANE;N1-Boc-1,7-heptanediamine;tert-Butyl 2,8-diaminooctanoate;TERT-BUTYL 7-AMINOHEPTYLCARBAMATE;1,7-Diaminoheptane, N1-BOC protected;Heptane-1,7-diamine, N-Boc protected
CBNumber: CB2672265
Molecular Formula: C12H26N2O2
Formula Weight: 230.35
MOL File: 99733-18-3.mol

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1-BOC-1,7-DIAMINOHEPTANE Property

Boiling point:: 340.9±25.0 °C(Predicted)
Density: 0.949±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 12.94±0.46(Predicted)
form: liquid
color: Colourless

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2921599090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B659093
Product name: 1-Boc-1,7-Diaminoheptane
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 094829
Product name: tert-Butyl 2,8-diaminooctanoate
Purity: 95+%
Packaging: 250mg
Price: $243
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB150788
Product name: 1-Boc-1,7-diaminoheptane
Packaging: 250mg
Price: $270
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB150788
Product name: 1-Boc-1,7-diaminoheptane
Packaging: 2g
Price: $1150
Updated: 2021/12/16

Matrix Scientific

Product number: 179965
Product name: (8-Aminooctyl)-carbamic acid tert-butyl ester
Purity: 95%
Packaging: 5g
Price: $1568
Updated: 2021/12/16

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1-BOC-1,7-DIAMINOHEPTANE Chemical Properties,Usage,Production

Description

tert-Butyl (7-aminoheptyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

tert-Butyl (7-aminoheptyl)carbamate (tert-Butyl 2,8-diaminooctanoate) is a PROTAC linker. tert-Butyl (7-aminoheptyl)carbamate can be used to synthesis CPD-10 (HY-168660)[1].

Synthesis

646-19-5

24424-99-5

99733-18-3

General procedure: preparation of mono-Boc-protected 1,7-diaminoheptane. Di-tert-butyl dicarbonate (Boc2O, 0.500 g, 2.291 mmol) was dissolved in chloroform (CHCl3, 10 mL) and the solution was added slowly and dropwise to a solution of 1,7-diaminoheptane (11.45 mmol) in chloroform (50 mL). The reaction mixture was stirred at room temperature for 24 hours. Subsequently, the reaction solution was concentrated and purified by fast column chromatography (silica gel, SiO2) using a gradient elution (0-10% MeOH) with chloroform/methanol (MeOH) containing 1% triethylamine (Et3N) to afford mono-Boc-protected 1,7-diaminoheptane ((tert-butyl (7-aminoheptyl)carbamate) as a colorless semi-solid (0.473 g, 90% yield ).1H NMR (CDCl3) δ: 4.52 (broad single peak, 1H), 3.12 (quadruple peak, J = 6.2 Hz, 2H), 2.70 (triple peak, J = 6.8 Hz, 2H), 1.43-1.23 (multiple peaks, 19H).

References

[1] Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1.

1-BOC-1,7-DIAMINOHEPTANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-1,7-DIAMINOHEPTANE Suppliers

China 62 France 1 Germany 1 India 1 Japan 1 United Kingdom 4 United States 10 Global 80

J & K SCIENTIFIC LTD.

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View Lastest Price from 1-BOC-1,7-DIAMINOHEPTANE manufacturers

Career Henan Chemical Co

Product: 1-BOC-1,7-DIAMINOHEPTANE 99733-18-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100KG
Release date: 2019-08-29

99733-18-3, 1-BOC-1,7-DIAMINOHEPTANERelated Search:

2-(AMINOETHYL)-1-N-BOC-PIPERIDINE 1-BOC-1,7-DIAMINOHEPTANE 2-(Boc-2-aminoethyl)piperidine 1,7-DIAMINOHEPTANE (1S,2S,3R,5S)-(2,6,6-TRIMETHYL-3-METHYLCARBAMOYL-BICYCLO[3.1.1]HEPT-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(4-AMINO-CYCLOHEXYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-1,3-DAMCH HCL AURORA KA-2546 AURORA KA-2545 METHYL N-A-BOC-B-(2-N-CBZ-PIPERIDINYL)ALANINATE AURORA KA-3055 AURORA KA-2548 BOC-DIAMINOHEPTANE HCL (1R,2R,3S,5R)-(2,6,6-TRIMETHYL-3-METHYLCARBAMOYL-BICYCLO[3.1.1]HEPT-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER AURORA KA-2542 AURORA KA-2547 (S)-A-FMOC-8-BOCAMINO-OCTANOIC ACID AURORA KA-2544

N-(tert-butoxycarbonyl)-1,7-heptanediamine

Heptane-1,7-diamine, N-Boc protected

1-BOC-1,7-DIAMINOHEPTANE

TERT-BUTYL 7-AMINOHEPTYLCARBAMATE

1,7-Diaminoheptane, N1-BOC protected

1,7-Diaminoheptane, N1-BOC protected 95%

tert-Butyl 7-aminoheptylcarbamate 1-Boc-1,7-diaminoheptane 1,7-Diaminoheptane N1-boc protected

N1-BOC-1,7-DIAMINOHEPTANE

Boc-DAHpt

N-t-Butyloxycarbonyl-1,7-diaminoheptane

tert-Butyl (7-aminohept-1-yl)carbamate

tert-Butyl 2,8-diaminooctanoate

Heptane-1,7-diamine, N-BOC protected 95%

tert-Butyl (7-aminohept-1-yl)carbamate, 1,7-Diaminoheptane, N-BOC protected

N-Boc-1,7-Diaminoheptane

N1-Boc-1,7-heptanediamine

Carbamic acid, N-(7-aminoheptyl)-, 1,1-dimethylethyl ester

Boc-NH-(CH2)7-NH2

1,1-Dimethylethyl N-(7-aminoheptyl)carbamate

1,1-Dimethylethyl N-(7-aminoheptyl)carbamate - [D94093]

99733-18-3

pharmacetical