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4-CYANO-3-METHYLISOQUINOLINE

Product Name
4-CYANO-3-METHYLISOQUINOLINE
CAS No.
161468-32-2
Chemical Name
4-CYANO-3-METHYLISOQUINOLINE
Synonyms
4-CYANO-3-METHYLISOQUINOLINE;4-Isoquinolinecarbonitrile, 3-methyl-
CBNumber
CB2676157
Molecular Formula
C11H8N2
Formula Weight
168.19
MOL File
Mol file
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4-CYANO-3-METHYLISOQUINOLINE Property

Boiling point:
330.9±22.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (50mg/ml)
form 
solid
pka
2.26±0.31(Predicted)
color 
white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PRK0000427
Product name
4-CYANO-3-METHYLISOQUINOLINE
Purity
95.00%
Packaging
5MG
Price
$504.06
Updated
2021/12/16
AccelPharmtech
Product number
D4708
Product name
3-methyl-4-Isoquinolinecarbonitrile
Purity
97.00%
Packaging
1G
Price
$2280
Updated
2021/12/16
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4-CYANO-3-METHYLISOQUINOLINE Chemical Properties,Usage,Production

Uses

4-Cyano-3-methylisoquinoline is an inhibitor for protein kinase A (PKA) with an IC50 of micromolar level. 4-Cyano-3-methylisoquinoline reverses morphine tolerance in mouse model[1].

Definition

ChEBI: 3-methyl-4-isoquinolinecarbonitrile is a member of isoquinolines.

Biological Activity

Cell permeable: yes', 'Primary Target
PKA', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 30 nM against protein kinase A

storage

+4°C

References

[1] Smith FL, et al., The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain Res. 2003 Sep 19;985(1):78-88. DOI:10.1016/s0006-8993(03)03170-6

4-CYANO-3-METHYLISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CYANO-3-METHYLISOQUINOLINE Suppliers

CHINA 13 United Kingdom 1 United States 3 Global 17
VDM Biochemicals
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0330-2528181
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0330-2528171
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sales@vdmbio.com
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United States
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Aladdin Scientific
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tp@aladdinsci.com
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United States
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EMD Biosciences, Inc.
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technical@calbiochem.com
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United States
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161468-32-2, 4-CYANO-3-METHYLISOQUINOLINERelated Search:

7-Bromo-4-methylisoquinoline 1-METHYLISOQUINOLINE 6-Chloro-3-methylisoquinoline 5-methylisoquinoline 3-Chloro-4-methylisoquinoline 7-bromo-6-methylisoquinoline 6-Bromo-3-methylisoquinoline 4-Amino-1-methylisoquinoline 5-Bromo-4-methylisoquinoline 1-CHLORO-5-METHYLISOQUINOLINE 6-fluoro-8-methylisoquinoline 5-bromo-8-methylisoquinoline 5-amino-6-methylisoquinoline 6-AMino-4-Methylisoquinoline 8-bromo-3-methylisoquinoline 3-Chloro-7-Methylisoquinoline 1,3-dimethylisoquinoline 7-fluoro-3-methylisoquinoline

  • 4-CYANO-3-METHYLISOQUINOLINE
  • 4-Isoquinolinecarbonitrile, 3-methyl-
  • 161468-32-2
  • A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A.