Description Discovery Synthesis Biological functions
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Proctolin

Description Discovery Synthesis Biological functions
Product Name
Proctolin
CAS No.
100930-02-7
Chemical Name
Proctolin
Synonyms
RYLPT;PROCTOLIN;proctolin acetate;ARG-TYR-LEU-PRO-THR;L-ARG-TYR-LEU-PRO-THR;H-ARG-TYR-LEU-PRO-THR-OH;Proctolin acetate salt;ARG-TYR-LEU-PRO-THR ACETATE SALT;(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid
CBNumber
CB2678878
Molecular Formula
C32H52N8O10
Formula Weight
708.8
MOL File
100930-02-7.mol
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Proctolin Property

storage temp. 
−20°C
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
P9005-78
Product name
Proctolin
Packaging
25mg
Price
$263
Updated
2021/12/16
Usbiological
Product number
463002
Product name
Proctolin
Packaging
1mg
Price
$326
Updated
2021/12/16
Biorbyt Ltd
Product number
orb372745
Product name
Proctolin
Purity
> 95%
Packaging
1mg
Price
$353.6
Updated
2021/12/16
Biorbyt Ltd
Product number
orb372745
Product name
Proctolin
Purity
> 95%
Packaging
5mg
Price
$688.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb372745
Product name
Proctolin
Purity
> 95%
Packaging
10mg
Price
$884
Updated
2021/12/16
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Proctolin Chemical Properties,Usage,Production

Description

Proctolin was the first bioactive peptide to be isolated from insect tissues and structurally characterized. Proctolin shows various activities, including a myotropic action, regulation of JH synthesis, and behavioral influences.

Discovery

Proctolin was first identified in 1975 from the whole body of the American cockroach Periplaneta americana, based upon its ability to stimulate hindgut contractions.

Synthesis

The gene encoding a proctolin precursor protein was first identified in the fruit fly Drosophila melanogaster. The predicted protein encoded by Proct has a single copy of the Arg-Tyr-Leu-Pro-Thr sequence that directly follows the predicted signal peptidase cleavage point flanked by a potential peptide cleaving site, and similar precursor structures are conserved in other insects and in noninsect arthropods. The proctolin gene has been found in a various arthropods except for Hymenoptera, Lepidoptera, and the yellow fever mosquito Aedes aegypt.Proctolin is thought to be synthesized and packaged into dense core vesicles in the cell body of neurons and then transported down the axon to the synaptic terminals.In arthropods, proctolin acts as a cotransmitter as well as a neurohormone.

Biological functions

Proctolin displays potent myotropic activity in the visceral, cardiac, and skeletal muscle from a range of insect species. In addition, proctolin may act as a releasing factor for adipokinetic hormone (AKH) and juvenile hormone (JH) in the locust.However, it does not regulate JH release in the cockroach. Moreover, proctolin plays a modulatory role in a neuronal circuit controlling sexual behavior in the bow-winged grasshopper Chorthippus biguttulus.

Uses

Proctolin is a neuropeptide present in insects and crustaceans.

Enzyme inhibitor

This insect neuromodulator/neurotransmitter/ neurohormone (FW = 648.76 g/mol; CAS : 100930-02-7; Sequence: L-Arg-L-Tyr-L-Leu-L-Pro-L-Thr) exerts its proctolinergic action by changing the way impulses are transmitted across a synapse, often assisting a more common neurotransmitter, such as glutamate. Mode of Action: Proctolin potently stimulates visceral and skeletal muscles contraction of a number of in insects. The Drosophila melanogaster proctolin receptor (CG6986) is an orphan G-protein coupled receptor and is strongly expressed in the head, the larval hindgut, the aorta and on neuronal endings in adult hearts. Unlike classical neurotransmitters, proctolin does not change the postsynaptic conductance. It also modulates reproductive tissue, stimulating contractions of the oviducts in the American cockroach Periplaneta americana, as well as Leucophaea maderae, L. migratoria, and spermathecae in L. migratoria and Rhodnius prolixus. Proctolin also speeds up heart rate in some insects. Target(s); dipeptidyl-peptidase III, or aminoenkephalinase.

Proctolin Preparation Products And Raw materials

Raw materials

Preparation Products

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Proctolin Suppliers

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4813
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6968
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
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58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921
Email
sales1@gotopbio.com
Country
CHINA
ProdList
2609
Advantage
58

100930-02-7, ProctolinRelated Search:


  • ARG-TYR-LEU-PRO-THR ACETATE SALT
  • proctolin acetate
  • ARG-TYR-LEU-PRO-THR
  • L-ARG-TYR-LEU-PRO-THR
  • H-ARG-TYR-LEU-PRO-THR-OH
  • (2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid
  • Proctolin acetate salt
  • PROCTOLIN
  • RYLPT
  • 100930-02-7
  • C30H48N8O8
  • Peptide