ChemicalBook > CAS DataBase List > 4-HYDROXYPHENYLRETINAMIDE

4-HYDROXYPHENYLRETINAMIDE

Product Name
4-HYDROXYPHENYLRETINAMIDE
CAS No.
65646-68-6
Chemical Name
4-HYDROXYPHENYLRETINAMIDE
Synonyms
hpr;4HPR;MK-4016;RETINAMIDE;CNTFRalpha;FENRETINIDE;Fenretinimide;Fenretinide(4-HPR);Fenretinide, >=98%;p-Hydroxyphenylretinamide
CBNumber
CB2680860
Molecular Formula
C26H33NO2
Formula Weight
391.55
MOL File
65646-68-6.mol
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4-HYDROXYPHENYLRETINAMIDE Property

Melting point:
162-163°C
Boiling point:
597.6±42.0 °C(Predicted)
Density 
1.081±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Orange solid
pka
9.98±0.26(Predicted)
color 
Yellow
λmax
362nm(MeOH)(lit.)
Merck 
14,3998
Stability:
Light Sensitive - Protect from Light Exposure
InChIKey
AKJHMTWEGVYYSE-FXILSDISSA-N
CAS DataBase Reference
65646-68-6(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
60-61-20/21/22-36/37/38
Safety Statements 
53-26-36/37/39-45-52
WGK Germany 
3
RTECS 
VH6420000
HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB1301585
Product name
ANTI-HPR (CENTER) antibody produced in rabbit
Purity
IgG fraction of antiserum, buffered aqueous solution
Packaging
400μl
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
H7779
Product name
Retinoic acid p-hydroxyanilide
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$212
Updated
2024/03/01
Sigma-Aldrich
Product number
390900
Product name
4-Hydroxyphenylretinamide
Purity
A synthetic amide of all-
Packaging
5mg
Price
$216
Updated
2024/03/01
TCI Chemical
Product number
H1464
Product name
all-trans-N-(4-Hydroxyphenyl)retinamide
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
H1464
Product name
all-trans-N-(4-Hydroxyphenyl)retinamide
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$693
Updated
2024/03/01
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4-HYDROXYPHENYLRETINAMIDE Chemical Properties,Usage,Production

Chemical Properties

4-HYDROXYPHENYLRETINAMIDE is Yellow Powder

Uses

4-HYDROXYPHENYLRETINAMIDE is an effective agent for the chemoprevention and growth modulation of oncogene-induced prostate cancer in the mouse prostate reconstitution model system and may be effective for the chemoprevention of human prostate cancer

Uses

A synthetic analog of Vitamin A.

Uses

Retinoic acid receptor ligand

Definition

ChEBI: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in ivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

General Description

Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.

Biological Activity

Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo . Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Biochem/physiol Actions

Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.

storage

Store at -20°C

References

[1] roberto benelli, stefano monteghirfo, roberta venè, francesca tosettiand nicoletta ferrari.the chemopreventive retinoid 4hpr impairs prostate cancer cell migration and invasion by interfering with fak/akt/gsk3β pathway andβ-catenin stability. molecular cancer.2010, 9:142-154.
[2] anita l. sabichi, denver t. hendricks, mary a. bober, michael j. birrer. retinoic acid receptorβexpression and growthinhibition of gynecologic cancer cells by thesynthetic retinoidn-(4-hydroxyphenyl) retinamide. journal of the national cancer institute. 1998, 90(8): 597-605.
[3] shi-yong sun, ping yue, and reuben lotan. induction of apoptosis by n-(4-hydroxyphenyl)retinamide andits association with reactive oxygen species, nuclearretinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.molecular pharmacology. 1999, 55:403–410.

4-HYDROXYPHENYLRETINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXYPHENYLRETINAMIDE Suppliers

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View Lastest Price from 4-HYDROXYPHENYLRETINAMIDE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Fenretinide 65646-68-6
Price
US $16.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
3kg
Release date
2022-01-10
Career Henan Chemical Co
Product
4-HYDROXYPHENYLRETINAMIDE 65646-68-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

65646-68-6, 4-HYDROXYPHENYLRETINAMIDERelated Search:

2-Chloro-5-iodobenzoic acid Retinal 4-HYDROXYPHENYLRETINAMIDE N-(4-CARBETHOXYPHENYL)RETINAMIDE,n-(4-ethoxycarbophenyl)retinamide,4-(carboethoxyphenyl)retinamide retinamide N-4-METHOXYPHENYLRETINAMIDE N-homocysteine thiolactonyl retinamide DECA-2,4,6,8-TETRAENAL METHOXY PEG-12 RETINAMIDE N-phenylretinamide N-(4-aminosulfonylphenyl)retinamide N-(2-HYDROXYPROPYL)RETINAMIDE 4-HYDROXYPHENYLRETINAMIDE--N N-(2-hydroxyethyl)retinamide N-(4-PIVALOYLOXYPHENYL)RETINAMIDE N-(3-HYDROXYPROPYL)RETINAMIDE RETINAMIDE,N-ETHYL- N-(2,3-DIHYDROXYPROPYL)RETINAMIDE

  • 4-HYDROXYPHENYLRETINAMIDE
  • 4HPR
  • FENRETINIDE
  • p-Hydroxyphenylretinamide
  • 4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide
  • (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide
  • Fenretinimide
  • Fenretinide(4-HPR)
  • RetinaMide,N-(4-hydroxyphenyl)-
  • Fenretinide N-(4-Hydroxyphenyl)retinamide
  • ANTI-HPR (CENTER) antibody produced in rabbit
  • all-trans-N-(4-Hydroxyphenyl)retinamide
  • Fenretinide, >=98%
  • N-(4-HYDROXYPHENYL)-ALL-TRANS RETINAMIDE
  • N-(4-HYDROXYPHENYL)RETINAMIDE
  • RETINOIC ACID P-HYDROXYANILIDE
  • RETINAMIDE
  • hpr
  • n-(4-hydroxyphenyl)-retinamid
  • 4-HPR; (4-HYDROXYPHENYL)RETINAMIDE
  • 4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem
  • (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide
  • CNTFRalpha
  • all-trans-N-(4-Hydroxyphenyl)retinamide &gt
  • MK-4016
  • Fenretinide D4Q: What is Fenretinide D4 Q: What is the CAS Number of Fenretinide D4 Q: What is the storage condition of Fenretinide D4 Q: What are the applications of Fenretinide D4
  • 65646-68-6
  • C26H33NO2
  • Cell Biology
  • Gene Regulation and Expression
  • PPAR and RXR Regulators
  • Cell Signaling and Neuroscience
  • BioChemical
  • Intracellular receptor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Retinoids
  • Drug Analogues
  • Inhibitors