ChemicalBook > CAS DataBase List > 4-HYDROXYPHENYLRETINAMIDE

4-HYDROXYPHENYLRETINAMIDE

Product Name
4-HYDROXYPHENYLRETINAMIDE
CAS No.
65646-68-6
Chemical Name
4-HYDROXYPHENYLRETINAMIDE
Synonyms
hpr;4HPR;MK-4016;RETINAMIDE;CNTFRalpha;FENRETINIDE;Fenretinimide;Fenretinide(4-HPR);Fenretinide, >=98%;p-Hydroxyphenylretinamide
CBNumber
CB2680860
Molecular Formula
C26H33NO2
Formula Weight
391.55
MOL File
65646-68-6.mol
More
Less

4-HYDROXYPHENYLRETINAMIDE Property

Melting point:
162-163°C
Boiling point:
597.6±42.0 °C(Predicted)
Density 
1.081±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Orange solid
pka
9.98±0.26(Predicted)
color 
Yellow
λmax
362nm(MeOH)(lit.)
Merck 
14,3998
Stability:
Light Sensitive - Protect from Light Exposure
InChIKey
AKJHMTWEGVYYSE-FXILSDISSA-N
CAS DataBase Reference
65646-68-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
60-61-20/21/22-36/37/38
Safety Statements 
53-26-36/37/39-45-52
WGK Germany 
3
RTECS 
VH6420000
HS Code 
2924297099
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB1301585
Product name
ANTI-HPR (CENTER) antibody produced in rabbit
Purity
IgG fraction of antiserum, buffered aqueous solution
Packaging
400μl
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
H7779
Product name
Retinoic acid p-hydroxyanilide
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$212
Updated
2024/03/01
Sigma-Aldrich
Product number
390900
Product name
4-Hydroxyphenylretinamide
Purity
A synthetic amide of all-
Packaging
5mg
Price
$216
Updated
2024/03/01
TCI Chemical
Product number
H1464
Product name
all-trans-N-(4-Hydroxyphenyl)retinamide
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
H1464
Product name
all-trans-N-(4-Hydroxyphenyl)retinamide
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$693
Updated
2024/03/01
More
Less

4-HYDROXYPHENYLRETINAMIDE Chemical Properties,Usage,Production

Chemical Properties

4-HYDROXYPHENYLRETINAMIDE is Yellow Powder

Uses

4-HYDROXYPHENYLRETINAMIDE is an effective agent for the chemoprevention and growth modulation of oncogene-induced prostate cancer in the mouse prostate reconstitution model system and may be effective for the chemoprevention of human prostate cancer

Uses

A synthetic analog of Vitamin A.

Uses

Retinoic acid receptor ligand

Definition

ChEBI: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in ivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

General Description

Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.

Biological Activity

Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo . Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Biochem/physiol Actions

Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.

storage

Store at -20°C

References

[1] roberto benelli, stefano monteghirfo, roberta venè, francesca tosettiand nicoletta ferrari.the chemopreventive retinoid 4hpr impairs prostate cancer cell migration and invasion by interfering with fak/akt/gsk3β pathway andβ-catenin stability. molecular cancer.2010, 9:142-154.
[2] anita l. sabichi, denver t. hendricks, mary a. bober, michael j. birrer. retinoic acid receptorβexpression and growthinhibition of gynecologic cancer cells by thesynthetic retinoidn-(4-hydroxyphenyl) retinamide. journal of the national cancer institute. 1998, 90(8): 597-605.
[3] shi-yong sun, ping yue, and reuben lotan. induction of apoptosis by n-(4-hydroxyphenyl)retinamide andits association with reactive oxygen species, nuclearretinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.molecular pharmacology. 1999, 55:403–410.

4-HYDROXYPHENYLRETINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-HYDROXYPHENYLRETINAMIDE Suppliers

Americas 1 Canada 1 China 161 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 10 United States 31 Global 213
Nanjing ShengSai Chemical Co., Ltd.
Tel
025-85205967 13951876367
Fax
025-85205967
Email
shengsaichem@163.com
Country
China
ProdList
811
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Lanzhou Angeli Biochemical Technology Co., Ltd.
Tel
0931-8235634 13321316780
Fax
+86(931) 4873122
Email
1455540579@qq.com
Country
China
ProdList
958
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Changzhou lan-Novo Pharmaceutical Co., Ltd.
Tel
+86-13915082169
Fax
-
Email
info@lannovopharm.com
Country
China
ProdList
62
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1931
Advantage
55
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4027
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28806
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
More
Less

View Lastest Price from 4-HYDROXYPHENYLRETINAMIDE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Fenretinide 65646-68-6
Price
US $16.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
3kg
Release date
2022-01-10
Career Henan Chemical Co
Product
4-HYDROXYPHENYLRETINAMIDE 65646-68-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

65646-68-6, 4-HYDROXYPHENYLRETINAMIDERelated Search:

2-Chloro-5-iodobenzoic acid Retinal 4-HYDROXYPHENYLRETINAMIDE N-(4-CARBETHOXYPHENYL)RETINAMIDE,n-(4-ethoxycarbophenyl)retinamide,4-(carboethoxyphenyl)retinamide retinamide N-4-METHOXYPHENYLRETINAMIDE N-homocysteine thiolactonyl retinamide DECA-2,4,6,8-TETRAENAL METHOXY PEG-12 RETINAMIDE N-phenylretinamide N-(4-aminosulfonylphenyl)retinamide N-(2-HYDROXYPROPYL)RETINAMIDE 4-HYDROXYPHENYLRETINAMIDE--N N-(2-hydroxyethyl)retinamide N-(4-PIVALOYLOXYPHENYL)RETINAMIDE N-(3-HYDROXYPROPYL)RETINAMIDE RETINAMIDE,N-ETHYL- N-(2,3-DIHYDROXYPROPYL)RETINAMIDE

  • 4-HYDROXYPHENYLRETINAMIDE
  • 4HPR
  • FENRETINIDE
  • p-Hydroxyphenylretinamide
  • 4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide
  • (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide
  • Fenretinimide
  • Fenretinide(4-HPR)
  • RetinaMide,N-(4-hydroxyphenyl)-
  • Fenretinide N-(4-Hydroxyphenyl)retinamide
  • ANTI-HPR (CENTER) antibody produced in rabbit
  • all-trans-N-(4-Hydroxyphenyl)retinamide
  • Fenretinide, >=98%
  • N-(4-HYDROXYPHENYL)-ALL-TRANS RETINAMIDE
  • N-(4-HYDROXYPHENYL)RETINAMIDE
  • RETINOIC ACID P-HYDROXYANILIDE
  • RETINAMIDE
  • hpr
  • n-(4-hydroxyphenyl)-retinamid
  • 4-HPR; (4-HYDROXYPHENYL)RETINAMIDE
  • 4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem
  • (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenamide
  • CNTFRalpha
  • all-trans-N-(4-Hydroxyphenyl)retinamide &gt
  • MK-4016
  • Fenretinide D4Q: What is Fenretinide D4 Q: What is the CAS Number of Fenretinide D4 Q: What is the storage condition of Fenretinide D4 Q: What are the applications of Fenretinide D4
  • 65646-68-6
  • C26H33NO2
  • Cell Biology
  • Gene Regulation and Expression
  • PPAR and RXR Regulators
  • Cell Signaling and Neuroscience
  • BioChemical
  • Intracellular receptor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Retinoids
  • Drug Analogues
  • Inhibitors