1-(2,6-DICHLOROBENZYL)PIPERAZINE

Product Name: 1-(2,6-DICHLOROBENZYL)PIPERAZINE
CAS No.: 102292-50-2
Chemical Name: 1-(2,6-DICHLOROBENZYL)PIPERAZINE
Synonyms: SBB009351;AKOS B014424;BAS 03082541;Oprea1_042275;Oprea1_177202;657832_ALDRICH;AG-670/40681823;BUTTPARK 36\08-57;ART-CHEM-BB B014424;TIMTEC-BB SBB009351
CBNumber: CB2682167
Molecular Formula: C11H14Cl2N2
Formula Weight: 245.15
MOL File: 102292-50-2.mol

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1-(2,6-DICHLOROBENZYL)PIPERAZINE Property

Melting point:: 54-62 °C
Boiling point:: 332.4±37.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 9.02±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C11H14Cl2N2/c12-10-2-1-3-11(13)9(10)8-15-6-4-14-5-7-15/h1-3,14H,4-8H2
InChIKey: WQTPGHSKQDVCQQ-UHFFFAOYSA-N
SMILES: N1(CC2=C(Cl)C=CC=C2Cl)CCNCC1
CAS DataBase Reference: 102292-50-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 657832
Product name: 1-(2,6-Dichlorobenzyl)piperazine
Purity: 97%
Packaging: 1g
Price: $55.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 657832
Product name: 1-(2,6-Dichlorobenzyl)piperazine
Purity: 97%
Packaging: 5g
Price: $184
Updated: 2023/01/07

TRC

Product number: D434745
Product name: 1-(2,6-Dichlorobenzyl)piperazine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD113235
Product name: 1-(2,6-Dichlorobenzyl)piperazine
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 028767
Product name: 1-(2,6-Dichlorobenzyl)piperazine
Packaging: 500mg
Price: $126
Updated: 2021/12/16

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1-(2,6-DICHLOROBENZYL)PIPERAZINE Chemical Properties,Usage,Production

Synthesis

110-85-0

20443-98-5

102292-50-2

1. Dissolve piperazine (112 mmol, 6.0 eq.) in THF (180 mL) at 0 °C to prepare a solution. 2. 2,6-dichlorobenzyl bromide (4.5 g, 18.8 mmol) was dissolved in THF (20 mL) to prepare a solution and slowly added dropwise to the THF solution of piperazine over 10 minutes. 3. After the dropwise addition was completed, the reaction mixture was slowly warmed to room temperature and stirred continuously for 24 hours. 4. Upon completion of the reaction, the THF solvent was removed by distillation under reduced pressure. 5. The crude product was resuspended in a mixture of dichloromethane (DCM) and water and extracted twice with DCM. 6. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. 7. The crude product was purified using combiflash fast chromatography eluting with a gradient of 0 to 20% methanol in DCM to afford the target compound 1-(2,6-dichlorobenzyl)piperazine (2.3 g, 50% yield). 8. The structure of the product was confirmed by 1H NMR, 13C NMR and HRMS. 1H NMR (400 MHz, methanol-d4) δ 7.62-7.30 (m, 2H), 7.23 (dd, J = 8.7, 7.4 Hz, 1H), 3.74 (s, 2H), 2.92-2.69 (m, 4H), 2.56 (t, J = 4.9 Hz, 4H). 13C NMR (101 MHz, MeOD) δ 136.76, 133.67, 129.18, 128.24, 56.55, 53.41, 44.95. HRMS (m/z): [M+] calculated value C11H14Cl2N2 245.15, measured value 245.06.

References

[1] Patent: WO2015/184349, 2015, A2. Location in patent: Paragraph 0221
[2] Patent: WO2016/176338, 2016, A1. Location in patent: Paragraph 0132
[3] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 22 - 38

1-(2,6-DICHLOROBENZYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,6-DICHLOROBENZYL)PIPERAZINE Suppliers

China 64 Germany 5 India 1 Russia 1 Switzerland 1 The Netherlands 1 United Kingdom 5 United States 13 Global 91

J & K SCIENTIFIC LTD.

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Shanghai Hanhong Scientific Co.,Ltd.

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Sigma-Aldrich

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Quzhou Rundong Chemical (Technology) Co.

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View Lastest Price from 1-(2,6-DICHLOROBENZYL)PIPERAZINE manufacturers

Career Henan Chemical Co

Product: 1-(2,6-DICHLOROBENZYL)PIPERAZINE 102292-50-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

102292-50-2, 1-(2,6-DICHLOROBENZYL)PIPERAZINERelated Search:

1-(3,4-DICHLOROBENZYL)PIPERAZINE 1-(2,4-DICHLOROBENZYL)PIPERAZINE 1-(2,6-DICHLOROBENZYL)PIPERAZINE 1-(2,6-DICHLOROBENZYL)PIPERAZINE HYDROCHLORIDE 1-(3,4-DICHLOROBENZYL)PIPERAZINE HYDROCHLORIDE 4-(3,4-Dichlorobenzyl)piperazine-1-carbaldehyde 1,4-Bis(3,4-dichlorobenzyl)piperazine 1-cinnamyl-4-(2,3-dichlorobenzyl)piperazine 1-(3-chlorophenyl)-4-(2,3-dichlorobenzyl)piperazine 1-(2,4-DICHLOROBENZYL)PIPERAZINE DIHYDROCHLORIDE 1-(2,6-DICHLOROBENZYL)-4-(2-NAPHTHYLSULFONYL)PIPERAZINE 1-(2,6-DICHLOROBENZYL)PIPERAZINE DIHYDROCHLORIDE 4-(2,6-DICHLOROBENZYL)PIPERAZINE-1-CARBALDEHYDE ETHYL 2-[1-(2,6-DICHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE BUTTPARK 82\11-11 2-(2,6-dichlorophenyl)-2-(piperazin-1-yl)acetonitrile 1-[(2,6-dichlorophenyl)carbonyl]piperazine 2-(2,6-dichlorophenyl)-2-(4-methylpiperazin-1-yl)ethan-1-amine

TIMTEC-BB SBB009351

AKOS B014424

BUTTPARK 36\08-57

ART-CHEM-BB B014424

1-(2,6-DICHLORO-BENZYL)-PIERPAZINE

1-(2,6-DICHLOROBENZYL)-PIPERAZINE >98%

1-(2,6-DICHLOROBENZYL)PIPERAZINE

1-(2,6-dichlorobenzyl)piperazine(SALTDATA: FREE)

6-Dichloro-benzyl)-pierpazine

1-[(2,6-dichlorophenyl)methyl]piperazine

657832_ALDRICH

AG-670/40681823

BAS 03082541

Oprea1_042275

Oprea1_177202

SBB009351

Piperazine, 1-[(2,6-dichlorophenyl)methyl]-

Dextropropoxyphene Hydrochloride Impurity 12

102292-50-2

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