ChemicalBook > CAS DataBase List > Enoximone

Enoximone

Product Name
Enoximone
CAS No.
77671-31-9
Chemical Name
Enoximone
Synonyms
Perfan;Pedane;RMI-17043;ENOXIMONE;MDL-17043;Fenoximone;Enoximone USP/EP/BP;4-Methyl-5-(4-(methylthio)benzoyl)-1H-imidazol-2(3H)-one;1,3-DIHYDRO-4-METHYL-5-[4-METHYLTHIOBENZOYL]-2H-IMIDAZOL-2-ONE;4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
CBNumber
CB2682723
Molecular Formula
C12H12N2O2S
Formula Weight
248.3
MOL File
77671-31-9.mol
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Enoximone Property

Melting point:
255-258°C
Density 
1.33
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 28 mg/mL, soluble
pka
10.37±0.70(Predicted)
form 
solid
color 
light yellow
CAS DataBase Reference
77671-31-9(CAS DataBase Reference)
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Safety

RIDADR 
3249
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1279
Product name
Enoximone
Purity
solid
Packaging
10mg
Price
$270
Updated
2024/03/01
Sigma-Aldrich
Product number
E1279
Product name
Enoximone
Purity
solid
Packaging
50mg
Price
$905
Updated
2022/05/15
Tocris
Product number
1693
Product name
Enoximone
Purity
≥99%(HPLC)
Packaging
10
Price
$169
Updated
2021/12/16
Tocris
Product number
1693
Product name
Enoximone
Purity
≥99%(HPLC)
Packaging
50
Price
$711
Updated
2021/12/16
Usbiological
Product number
255248
Product name
Enoximone
Packaging
10mg
Price
$423
Updated
2021/12/16
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Enoximone Chemical Properties,Usage,Production

Description

Enoximone is a phosphodiesterase inhibitor indicated for selective use as a cardiostimulant in heart transplant patient maintenance. It is currently being investigated for other indications including acute congestive heart failure.

Originator

Merrell Dow (USA)

Uses

Enoximone is a phosphodiesterase inhibitor used in the treatment of congestive heart failure and is selective to phosphodiesterase 3. Potent PDE-3 inhibitor.

Definition

ChEBI: Enoximone is an aromatic ketone.

brand name

Perfan IV

Biological Activity

Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro .

Biochem/physiol Actions

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

storage

Store at +4°C

Enoximone Preparation Products And Raw materials

Raw materials

NITROUS ACID Ethyl acetate

Preparation Products

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Enoximone Suppliers

China 61 Europe 4 Japan 1 Switzerland 1 United Kingdom 7 United States 23 USA 1 Global 98
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View Lastest Price from Enoximone manufacturers

Dideu Industries Group Limited
Product
Enoximone 77671-31-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-12
Career Henan Chemica Co
Product
Enoximone 77671-31-9
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-10-28

77671-31-9, EnoximoneRelated Search:

Methyl salicylate Imidazole Hexamethylphosphoramide Dihydromyrcenol 1-Methylimidazole Basic Violet 1 Phenylmethylsulfonyl fluoride Tribenuron methyl Methylparaben Methyl acrylate Methanol Kresoxim-methyl 1-(2,6-Dimethylphenoxy)-2-propanamine Methyl 4-Ethyl-1,3-dihydro-imidazol-2-one 4,5-DIMETHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE 4-ACETYL-5-METHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE enoximone sulfoxide

  • ENOXIMONE
  • 2H-Imidazol-2-one, 1,3-dihydro-4-methyl-5-(4-(methylthio)benzoyl)-
  • Fenoximone
  • MDL-17043
  • Pedane
  • Perfan
  • RMI-17043
  • 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
  • 1,3-DIHYDRO-4-METHYL-5-[4-METHYLTHIOBENZOYL]-2H-IMIDAZOL-2-ONE
  • 4-Methyl-5-[4-(methylthio)benzoyl]-1,3-dihydro-2H-imidazol-2-one
  • Enoximone USP/EP/BP
  • 4-Methyl-5-(4-(methylthio)benzoyl)-1H-imidazol-2(3H)-one
  • inhibit,Enoximone,bronchodilatory,CD11b,eosinophils,vasodilating,Phosphodiesterase (PDE),airway,cAMP,PDE3,PDE4A,Inhibitor,anti-inflammatory,Antiasthma
  • 77671-31-9
  • BioChemical
  • Cell Signaling and Neuroscience
  • G Proteins and Cyclic Nucleotides
  • Phosphodiesterase Inhibitors
  • Cyclic Nucleotide Metabolism
  • Cell Biology
  • APIs
  • API