Enoximone

ChemicalBook > CAS DataBase List > Enoximone

Product Name: Enoximone
CAS No.: 77671-31-9
Chemical Name: Enoximone
Synonyms: Perfan;Pedane;RMI-17043;ENOXIMONE;MDL-17043;Fenoximone;Enoximone USP/EP/BP;4-Methyl-5-(4-(methylthio)benzoyl)-1H-imidazol-2(3H)-one;1,3-DIHYDRO-4-METHYL-5-[4-METHYLTHIOBENZOYL]-2H-IMIDAZOL-2-ONE;4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
CBNumber: CB2682723
Molecular Formula: C12H12N2O2S
Formula Weight: 248.3
MOL File: 77671-31-9.mol

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Enoximone Property

Melting point:: 255-258°C
Density: 1.33
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: 28 mg/mL, soluble
pka: 10.37±0.70(Predicted)
form: solid
color: light yellow
CAS DataBase Reference: 77671-31-9(CAS DataBase Reference)

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Safety

RIDADR: 3249
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E1279
Product name: Enoximone
Purity: solid
Packaging: 10mg
Price: $270
Updated: 2024/03/01

Sigma-Aldrich

Product number: E1279
Product name: Enoximone
Purity: solid
Packaging: 50mg
Price: $905
Updated: 2022/05/15

Tocris

Product number: 1693
Product name: Enoximone
Purity: ≥99%(HPLC)
Packaging: 10
Price: $169
Updated: 2021/12/16

Tocris

Product number: 1693
Product name: Enoximone
Purity: ≥99%(HPLC)
Packaging: 50
Price: $711
Updated: 2021/12/16

Usbiological

Product number: 255248
Product name: Enoximone
Packaging: 10mg
Price: $423
Updated: 2021/12/16

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Enoximone Chemical Properties,Usage,Production

Description

Enoximone is a phosphodiesterase inhibitor indicated for selective use as a cardiostimulant in heart transplant patient maintenance. It is currently being investigated for other indications including acute congestive heart failure.

Originator

Merrell Dow (USA)

Uses

Enoximone is a phosphodiesterase inhibitor used in the treatment of congestive heart failure and is selective to phosphodiesterase 3. Potent PDE-3 inhibitor.

Definition

ChEBI: Enoximone is an aromatic ketone.

brand name

Perfan IV

Biological Activity

Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro .

Biochem/physiol Actions

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

storage

Store at +4°C

Enoximone Preparation Products And Raw materials

Raw materials

NITROUS ACID Ethyl acetate

Preparation Products

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View Lastest Price from Enoximone manufacturers

Career Henan Chemica Co

Product: Enoximone 77671-31-9
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-10-28

77671-31-9, EnoximoneRelated Search:

Methyl salicylate Imidazole Hexamethylphosphoramide Dihydromyrcenol 1-Methylimidazole Basic Violet 1 Phenylmethylsulfonyl fluoride Tribenuron methyl Methylparaben Methyl acrylate Methanol Kresoxim-methyl 1-(2,6-Dimethylphenoxy)-2-propanamine Methyl 4-Ethyl-1,3-dihydro-imidazol-2-one 4,5-DIMETHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE 4-ACETYL-5-METHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE enoximone sulfoxide

ENOXIMONE

2H-Imidazol-2-one, 1,3-dihydro-4-methyl-5-(4-(methylthio)benzoyl)-

Fenoximone

MDL-17043

Pedane

Perfan

RMI-17043

4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one

1,3-DIHYDRO-4-METHYL-5-[4-METHYLTHIOBENZOYL]-2H-IMIDAZOL-2-ONE

4-Methyl-5-[4-(methylthio)benzoyl]-1,3-dihydro-2H-imidazol-2-one

Enoximone USP/EP/BP

4-Methyl-5-(4-(methylthio)benzoyl)-1H-imidazol-2(3H)-one

inhibit,Enoximone,bronchodilatory,CD11b,eosinophils,vasodilating,Phosphodiesterase (PDE),airway,cAMP,PDE3,PDE4A,Inhibitor,anti-inflammatory,Antiasthma

77671-31-9

BioChemical

Cell Signaling and Neuroscience

G Proteins and Cyclic Nucleotides

Phosphodiesterase Inhibitors

Cyclic Nucleotide Metabolism

Cell Biology

APIs

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