4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE

Product Name: 4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE
CAS No.: 16184-89-7
Chemical Name: 4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE
Synonyms: 1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-one;1-(4-Bromophenyl)-2,2,2-trifluoroethanone;4-bromo-α,α,α-trifluoroacetophen;-Bromo-2,2,2-trifluoroacetophenone;4-bromo-α,α,α-trifluoroacetophenone;4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE;4'-Bromo-2,2,2-trifluoroacetophenone 99%;4'-Bromo-2,2,2-trifluoroacetophenone?New;4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE, >=98%;1-(4-broMophenyl)-2,2,2-trifluoro-1-ethanone
CBNumber: CB2687889
Molecular Formula: C8H4BrF3O
Formula Weight: 253.02
MOL File: 16184-89-7.mol

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4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE Property

Melting point:: 26-30 °C(lit.)
Boiling point:: 95 °C4 mm Hg(lit.)
Density: 1.662 g/mL at 25 °C(lit.)
refractive index: 1.4610 (estimate)
Flash point:: 205 °F
storage temp.: Inert atmosphere,Room Temperature
form: low melting crystals
color: Colourless
Water Solubility: Slightly soluble in water.
Sensitive: Moisture Sensitive
BRN: 1956460
InChI: InChI=1S/C8H4BrF3O/c9-6-3-1-5(2-4-6)7(13)8(10,11)12/h1-4H
InChIKey: IHGSAQHSAGRWNI-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(Br)C=C1)C(F)(F)F
CAS DataBase Reference: 16184-89-7

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 403229
Product name: 4′-Bromo-2,2,2-trifluoroacetophenone
Purity: ≥98%
Packaging: 5g
Price: $41.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 403229
Product name: 4′-Bromo-2,2,2-trifluoroacetophenone
Purity: ≥98%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: B2274
Product name: 1-(4-Bromophenyl)-2,2,2-trifluoroethanone
Purity: min. 98.0 %
Packaging: 5G
Price: $81
Updated: 2025/07/31

TRC

Product number: B688395
Product name: 4’-Bromo-2,2,2-trifluoroacetophenone
Packaging: 5g
Price: $360
Updated: 2021/12/16

TRC

Product number: B688395
Product name: 4’-Bromo-2,2,2-trifluoroacetophenone
Packaging: 1g
Price: $120
Updated: 2021/12/16

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4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

Clear light yellow liquid

Uses

4?-Bromo-2,2,2-trifluoroacetophenone may be used in the preparation of carbonyl-bridged bithiazole derivatives. Also used as a reagent to synthesize MK-5046, a selective Bombesin receptor subtype-3 agonist used to treat obesity.

Synthesis

383-63-1

583-53-9

16184-89-7

A. Synthesis of 1-(4-bromophenyl)-2,2,2-trifluoro-1-acetophenone 1,2-Dibromobenzene (6.0 g, 0.025 mol) was dissolved in 59 mL of anhydrous tetrahydrofuran in a flame-dried flask. The solution was cooled to -78 °C in a dry ice/acetone bath and n-butyllithium (2.56 M hexane solution, 9.8 mL, 0.025 mol) was slowly added dropwise, keeping the reaction temperature below -60 °C during the reaction. After addition, the reaction mixture was stirred at -78 °C for 1 hour. The solution was then added dropwise via cannula to a solution of ethyl trifluoroacetate (3.56 g, 0.0257 mol) in 36 mL of ether and cooled to -78 °C. After addition, the reaction mixture was stirred at -70 °C for 15 min and then gradually warmed to room temperature. The reaction mixture was partitioned between ether and saturated aqueous ammonium chloride solution, and the pH of the aqueous phase was adjusted to about pH = 2 by dropwise addition of 1 M HCl. The organic phase was washed with brine, dried over MgSO4, filtered, and concentrated to give 10 g (> 100%) of crude compound A, which was used without further purification for the next reaction.

References

[1] Patent: EP768305, 1997, A1

4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE Suppliers

China 178 Germany 2 India 2 Italy 1 Switzerland 1 United Kingdom 3 United States 15 Global 202

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View Lastest Price from 4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE 16184-89-7
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-BROMO-2,2,2-TRIFLUOROACETOPHENONE 16184-89-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-BROMO-2,2,2-TRIFLUOROACETOPHENONE 16184-89-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

16184-89-7, 4'-BROMO-2,2,2-TRIFLUOROACETOPHENONERelated Search:

3'-BROMO-2,2,2-TRIFLUOROACETOPHENONE 1-(4-BROMO-3-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE 1-Bromo-4-(2,2,2-trifluoroethyl)benzene Trifluoroacetophenone 4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE

4'-Bromo-2,2,2-trifluoroacetophenone 99%

Ethanone, 1-(4-broMophenyl)-2,2,2-trifluoro-

1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-one, 2-(4-Bromophenyl)-2-oxo-1,1,1-trifluoroethane

4-BROMO-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE

4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE

4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE, >=98%

1-(4-Bromophenyl)-2,2,2-trifluoroethanone

4-bromo-α,α,α-trifluoroacetophenone

1-(4-broMophenyl)-2,2,2-trifluoro-1-ethanone

1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-one

-Bromo-2,2,2-trifluoroacetophenone

4-bromo-α,α,α-trifluoroacetophen

4'-Bromo-2,2,2-trifluoroacetophenone?New

4′-Bromo-2,2,2-trifluoroacetophenone, CAS 16184-89-7

4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE 98%min

16184-89-7

BrC6H4COCF3

ARYL HALIDE

Building Blocks

Carbonyl Compounds

C7 to C8

Ketones

Organic Building Blocks

Fluorine series

Building Blocks

C7 to C8

Carbonyl Compounds

Chemical Synthesis

Ketones

Organic Building Blocks