ChemicalBook > CAS DataBase List > BRL 54443

BRL 54443

Product Name
BRL 54443
CAS No.
57477-39-1
Chemical Name
BRL 54443
Synonyms
CS-1781;BRL 54443;BRL 54443 HCl;BRL 54443, >=98%;BRL-54443;BRL54443;BRL 54443 USP/EP/BP;BRL54443;BRL 54443;BRL-54443;3-(1-methylpiperidin-4-yl)-1H-indol-5-ol;3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol;1H-Indol-5-ol, 3-(1-Methyl-4-piperidinyl)-
CBNumber
CB2690838
Molecular Formula
C14H18N2O
Formula Weight
230.31
MOL File
Mol file
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BRL 54443 Property

Boiling point:
431.5±45.0 °C(Predicted)
Density 
1.196
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL
form 
solid
pka
10.08±0.40(Predicted)
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21263
Product name
BRL 54443
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21263
Product name
BRL 54443
Purity
≥98%
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
21263
Product name
BRL 54443
Purity
≥98%
Packaging
25mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
21263
Product name
BRL 54443
Purity
≥98%
Packaging
50mg
Price
$384
Updated
2024/03/01
Tocris
Product number
1129
Product name
BRL54443
Packaging
50
Price
$495
Updated
2021/12/16
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BRL 54443 Chemical Properties,Usage,Production

Uses

BRL-53443 is a potent 5-HT and dopamine receptor agonist. Neuroresearch product.

Definition

ChEBI: 3-(1-methyl-4-piperidinyl)-1H-indol-5-ol is a member of hydroxyindoles.

Biological Activity

A potent 5-ht 1E/1F receptor agonist (pEC 50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pK i values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT 1E , 1F , 1A , 1B , 1D , 2A , 2B , 2C , 4 , 7 , D 2 and D 3 receptors respectively). Induces 5-HT 2A receptor-mediated mouse aortic contraction in vitro (pEC 50 = 6.52). Active in vivo .

storage

+4°C (desiccate)

References

1. a.m. brown, k. avenell, t j. young et al. brl 54443, a potent agonist with selectivity for human cloned 5-ht1e and 5-ht1f receptors. 1998. br.j.pharmacol. 123 233p.2. s. lightowler, t. stean, n. upton et al. effect of brl 54443 (3-(1-methylpiperidin-4-yl)-1h-indol-5-ol), a 5-ht1e/1f receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. 1998. br.j.pharmacol. 123 237p.3. mckune cm, watts sw. characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. j pharmacol exp ther. 2001 apr;297(1):88-95.4. janssen p, tack j, sifrim d et al. influence of 5-ht1 receptor agonists on feline stomach relaxation. eur j pharmacol. 2004 may 25;492(2-3):259-67.

BRL 54443 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRL 54443 Suppliers

China 116 India 1 Japan 1 United Kingdom 4 United States 18 Global 140
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View Lastest Price from BRL 54443 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Cobicistat 57477-39-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
BRL 54443 57477-39-1
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

57477-39-1, BRL 54443Related Search:

Hexamidine piperidine 3-Methylpiperidin-3-ol HCl Panobinostat Lenalidomide Pomalidomide Erlotinib hydrochloride Dacomitinib PLX4032

  • BRL 54443
  • 5-HYDROXY-3-(1-METHYLPIPERIDIN-4-YL)-1H-INDOLE
  • 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
  • 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol BRL 54443
  • 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
  • 1H-Indol-5-ol, 3-(1-Methyl-4-piperidinyl)-
  • BRL 54443 HCl
  • BRL-54443;BRL54443
  • BRL 54443, >=98%
  • BRL54443;BRL 54443;BRL-54443
  • CS-1781
  • BRL 54443 USP/EP/BP
  • 57477-39-1
  • Inhibitors