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PHOLCODINE

Product Name
PHOLCODINE
CAS No.
509-67-1
Chemical Name
PHOLCODINE
Synonyms
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]morphinan-6-ol;Memine;pha-ol;Codylin;Ethnine;Galphol;pholtex;Dia-tuss;Folkodin;Hibernyl
CBNumber
CB2704131
Molecular Formula
C23H30N2O4
Formula Weight
398.5
MOL File
509-67-1.mol
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PHOLCODINE Property

Melting point:
91°C
Boiling point:
521.67°C (rough estimate)
Density 
1.1772 (rough estimate)
refractive index 
1.6300 (estimate)
solubility 
Sparingly soluble in water, freely soluble in acetone and in ethanol (96 per cent). It dissolves in dilute mineral acids.
form 
Solid
pka
pKa 5.30(50% aq EtOH) (Uncertain)
color 
Light Brown
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Safety

Toxicity
LD50 oral in mouse: 1gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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PHOLCODINE Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

antimalarial derivative of natural artemisinin

Uses

Antitussive; an opioid cough suppressant. Controlled Substance.

Definition

ChEBI: A morphinane alkaloid that is a derivative of morphine with a 2-morpholinoethyl group at the 3-position.

brand name

Ethnine Simplex (Purdue Frederick).

PHOLCODINE Preparation Products And Raw materials

Raw materials

Preparation Products

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PHOLCODINE Suppliers

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509-67-1, PHOLCODINERelated Search:

PHOLCODINE ETHYLMORPHINE PHOLCODINE - REFERENCE SPECTRUM PHOLCODINE IMP. A (PHARMEUROPA) AS HEMISULPHATE PENTAHEMIHYDRATE: MORPHINE HEMISULPHATE PENTAHEMIHYDRATE[CONTROLLED SUBSTANCE PHOLCODINE IMP. B (PHARMEUROPA) AS PHOSPHATE HEMIHYDRATE: CODEINE PHOSPHATE HEMIHYDRATE[CONTROLLED SUBSTANCE] Pholcodine - * narc PHOLCODINE IMP. A (PHARMEUROPA) AS HYDROCHLORIDE TRIHYDRATE: MORPHINE HYDROCHLORIDE TRIHYDRATE [CONTROLLED SUBSTANCE] CHEMBRDG-BB 9071306 o-bis(2,3-epoxypropoxy)benzene Pholcodine for peak identification - * narc PHOLCODINE IMP. B (PHARMEUROPA) AS MONOHYDRATE: CODEINE MONOHYDRATE[CONTROLLED SUBSTANCE] PHOLCODINE-N-OXIDE 2-(3,4-DIMETHYL-PHENOXY)-ETHYLAMINE CHEMBRDG-BB 9071974 2-(2-ETHOXY-PHENOXY)-ETHYLAMINE CHEMBRDG-BB 9071359 Piperidine, 2-[(4-ethoxyphenyl)methyl]- (9CI)

  • (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]morphinan-6-ol
  • 3-(2-(4-Morpholinyl)ethyl)morphine
  • 3-(2-Morpholinoethyl)morphine
  • 3-Morpholylaethylmorphin
  • 3-o-(2-morpholinoethyl)-morphin
  • 7,8-didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-al
  • 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-ol
  • beta-Morpholinoethylmorphine
  • beta-Morpholinylethylmorphine
  • Codylin
  • Dia-tuss
  • Ethnine
  • Ethnine Simplex
  • Folcodine
  • Folkodin
  • Galenphol
  • Galphol
  • Glycodine
  • Hibernyl
  • Homocodeine
  • Memine
  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)-
  • tussokon
  • Weifacodine
  • PHOLCODINE
  • O3-(2-morpholinoethyl)morphine
  • Pholcodine (PI)
  • (5α,6α)-7,8-Didehydro-4,5-epoxy-17-Methyl-3-[2-(4-Morpholinyl)ethoxy]Morphinan-6-ol
  • 3-O-(2-Morpholinoethyl)Morphine
  • 7,8-Didehydro-4,5α-epoxy-17-Methyl-3-(2-Morpholinoethoxy)Morphinan-6α-ol
  • Biocalyptol
  • Folcodin
  • Neocodine
  • O-2-MorpholinoethylMorphine
  • Pholcodine for peak identification
  • (4R,4aR,7S,7aR,12bS)-3-methyl-9-(2-morpholin-4-ylethoxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol
  • morphinan-6-alpha-ol,7,8-didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoet
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]-, (5alpha,6alpha)-
  • Morphine, 0<sup>3</sup>-(2-morpholinoethyl)-
  • Morphine, 3-O-(2-morpholinoethyl)-
  • Morpholinylethylmorphine
  • Neocodin
  • o(sup3)-(2-morpholinoethyl)-morphin
  • o(sup3)-(2-morpholinoethyl)morphine
  • O<sup>3</sup>-(2-Morpholinoethyl)morphine
  • Pectolin
  • pha-ol
  • Pholcodin
  • pholtex
  • Prodromine
  • Tetrahydro-1,4-oxazinylmethylcodeine
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]-, (5α,6α)-
  • 509-67-1
  • C23H30N2O4
  • C23H30N2O4H2O
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals