XANTHOQUINODIN A1 Property

Boiling point:

859.6±65.0 °C(Predicted)

Density 

1.74±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble

form 

A solid

pka

4.50±1.00(Predicted)

Hazard and Precautionary Statements (GHS)

XANTHOQUINODIN A1 Chemical Properties,Usage,Production

Biological Activity

Xanthoquinodin A1 is a fungal metabolite that has been found in Humicola and has diverse biological activities.1,2 It inhibits E. tenella schizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1 Xanthoquinodin A1 is active against B. subtilis, M. luteus, S. aureus, A. laidlawii, and B. fragilis in a disc assay when used at a concentration of 1 mg/ml. It is also active against B. cereus (MIC = 0.44 μM).2 Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cancer cells.

References

1.Tabata, N., Suzumura, Y., Tomoda, H., et al.Xanthoquinodins, new anticoccidial agents produced by Humicola sp. Production, isolation and physico-chemical and biological propertiesJ. Antibiot. (Tokyo)46(5)749-755(1993) 2.Tantapakul, C., Promgool, T., Kanokmedhakul, K., et al.Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) MartNat. Prod. Res.34(4)494-502(2020)