ChemicalBook > CAS DataBase List > GUANIDINOSUCCINIC ACID

GUANIDINOSUCCINIC ACID

Product Name: GUANIDINOSUCCINIC ACID
CAS No.: 6133-30-8
Chemical Name: GUANIDINOSUCCINIC ACID
Synonyms: NSC49078;NSC 49078;NSC-49078;guanidinosuccic acid;n-amidino-asparticaci;GUANIDINOSUCCINIC ACID;N-amidinoaspartic acid;N-amidino-L-asparticaci;2-Guanidinosuccinic acid;L-N-Amidinoaspartic acid
CBNumber: CB2710712
Molecular Formula: C5H9N3O4
Formula Weight: 175.14
MOL File: 6133-30-8.mol

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GUANIDINOSUCCINIC ACID Property

Boiling point:: 344.5±52.0 °C(Predicted)
Density: 1.74±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
form: A solid
pka: 3.22±0.23(Predicted)
color: White to off-white

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Safety

WGK Germany: 3
RTECS: CI9098875

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0062315
Product name: Guanidinosuccinicacid
Purity: >98.0%
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0062315
Product name: Guanidinosuccinicacid
Purity: >98.0%
Packaging: 50mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0062315
Product name: Guanidinosuccinicacid
Purity: >98.0%
Packaging: 100mg
Price: $180
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573202
Product name: Guanidinosuccinic acid
Packaging: 100mg
Price: $324.7
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573202
Product name: Guanidinosuccinic acid
Packaging: 250mg
Price: $493
Updated: 2021/12/16

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GUANIDINOSUCCINIC ACID Chemical Properties,Usage,Production

Uses

Guanidinosuccinic acid is a nitrogenous metabolite.

Definition

ChEBI: An aspartic acid derivative comprising L-aspartic acid carrying an N-amidino substituent.

in vivo

Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients^[1]. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD₅₀ (and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD₅₀ of 579 (445-756) mg/kg. The CD₅₀ of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration^[2].

IC 50

Human Endogenous Metabolite

References

[1] Milstien S, et al. Role of intestinal microflora in the metabolism of guanidinosuccinic acid. J Bacteriol. 1973 May;114(2):641-4. DOI:10.1128/jb.114.2.641-644.1973
[2] D'Hooge R, et al. Behavioral toxicity of guanidinosuccinic acid in adult and young mice. Toxicol Lett. 1992 Dec;64-65 Spec No:773-7. DOI:10.1016/0378-4274(92)90261-h

GUANIDINOSUCCINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GUANIDINOSUCCINIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: GUANIDINOSUCCINIC ACID 6133-30-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

6133-30-8, GUANIDINOSUCCINIC ACIDRelated Search:

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NSC 49078

NSC49078

NSC-49078

Guanidinosuccinic acid, 10 mM in DMSO

6133-30-8

C5H9O4N3

C5H9N3O4

A - H

Amino Acids and Peptides

BioChemical

Biochemicals and Reagents

Modified Amino Acids

amino acids